(1R,2R,4R,6R)-1-methyl-6-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol

Base Information

Chemical Name:(1R,2R,4R,6R)-1-methyl-6-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol
CAS No.:1298087-20-3
Molecular Formula:C₂₆H₃₂O₄SSi
Molecular Weight:468.689
Hs Code.:

Synonyms:(1R,2R,4R,6R)-1-methyl-6-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol

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Chemical Property of (1R,2R,4R,6R)-1-methyl-6-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol

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Technology Process of (1R,2R,4R,6R)-1-methyl-6-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol

There total 4 articles about (1R,2R,4R,6R)-1-methyl-6-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1316735-67-7
C₂₆H₃₂O₂SSi

: 1298087-20-3
(1R,2R,4R,6R)-1-methyl-6-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol

: 1298087-06-5
(1R,2R,4R,6R)-1-methyl-2-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1016/j.tetlet.2011.01.152

Reference yield:

: 36616-60-1
(1R,4R,6R)-4-isopropenyl-1-methyl-7-oxabicyclo[4.1.0]heptan-2-one

: 1298087-20-3
(1R,2R,4R,6R)-1-methyl-6-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol

: 1298087-06-5
(1R,2R,4R,6R)-1-methyl-2-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: 15 h / -78 - 0 °C

2.1: C₅H₈O*C₆Co₂O₆ / 1,2-dichloro-ethane / 3 h / 50 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

With n-butyllithium; C₅H₈O*C₆Co₂O₆; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2011.01.152

Reference yield:

: 6485-40-1,2244-16-8
(R)-Carvone

: 1298087-20-3
(1R,2R,4R,6R)-1-methyl-6-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol

: 1298087-06-5
(1R,2R,4R,6R)-1-methyl-2-((Z)-2-(dimethyl(phenyl)silyl)-2-(phenylsulfonyl)vinyl)-4-(prop-1-en-2-yl)-7-oxa-bicyclo[4.1.0]heptan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; sodium hydroxide / methanol; water / 1 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran / -78 °C

2.2: 15 h / -78 - 0 °C

3.1: C₅H₈O*C₆Co₂O₆ / 1,2-dichloro-ethane / 3 h / 50 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

With n-butyllithium; C₅H₈O*C₆Co₂O₆; dihydrogen peroxide; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2011.01.152