tert-Butyl-[(3R,5S,7R,9S)-10-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,5,7,9-tetrakis-methoxymethoxy-decyloxy]-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-[(3R,5S,7R,9S)-10-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,5,7,9-tetrakis-methoxymethoxy-decyloxy]-diphenyl-silane
CAS No.:126396-23-4
Molecular Formula:C₃₉H₆₄O₁₁Si
Molecular Weight:737.016
Hs Code.:

Synonyms:tert-Butyl-[(3R,5S,7R,9S)-10-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,5,7,9-tetrakis-methoxymethoxy-decyloxy]-diphenyl-silane

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Chemical Property of tert-Butyl-[(3R,5S,7R,9S)-10-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,5,7,9-tetrakis-methoxymethoxy-decyloxy]-diphenyl-silane

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Technology Process of tert-Butyl-[(3R,5S,7R,9S)-10-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,5,7,9-tetrakis-methoxymethoxy-decyloxy]-diphenyl-silane

There total 10 articles about tert-Butyl-[(3R,5S,7R,9S)-10-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,5,7,9-tetrakis-methoxymethoxy-decyloxy]-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-30-2
chloromethyl methyl ether

: 127725-26-2,127761-10-8
(2S,4S,6R,8R)-10-(tert-Butyl-diphenyl-silanyloxy)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6,8-bis-methoxymethoxy-decane-2,4-diol

: 126396-23-4
tert-Butyl-[(3R,5S,7R,9S)-10-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,5,7,9-tetrakis-methoxymethoxy-decyloxy]-diphenyl-silane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/S0040-4039(00)99366-3

Reference yield:

: 125975-53-3,147220-48-2,116996-54-4
(2S)-O-(tert-butyldiphenylsilyl)-1,2-epoxybutan-4-ol

: 126396-23-4
tert-Butyl-[(3R,5S,7R,9S)-10-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,5,7,9-tetrakis-methoxymethoxy-decyloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / n-BuLi / tetrahydrofuran / -20 °C

2: 81 percent / MeI-CaCO₃ / acetonitrile; H₂O

3: LiAlH(OtBu)3-LiI / diethyl ether / 1 h / -78 °C / 1,3-asymmetric reduction of the β-alkoxy β'-hydroxy ketone with variation of reagent and temperature

4: iPr₂EtN / CH₂Cl₂ / 0 °C

5: pyridinium p-toluenesulfonate (PPTS) / methanol / 45 °C

7: 90 percent / n-BuLi / tetrahydrofuran / -20 °C

8: 90 percent / MeI-CaCO₃ / acetonitrile; H₂O

9: 89 percent Spectr_. / LiAlH(OtBu)3-LiI / diethyl ether / 1 h / 0 °C

10: iPr₂EtN / CH₂Cl₂ / 0 °C

With n-butyllithium; MeI-CaCO₃; pyridinium p-toluenesulfonate; lithium tri-t-butoxyaluminum hydride; N-ethyl-N,N-diisopropylamine; lithium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(00)99366-3

Reference yield:

: 127725-30-8
((3R,5S)-3,5-Bis-methoxymethoxy-6-(S)-oxiranyl-hexyloxy)-tert-butyl-diphenyl-silane

: 126396-23-4
tert-Butyl-[(3R,5S,7R,9S)-10-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,5,7,9-tetrakis-methoxymethoxy-decyloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / n-BuLi / tetrahydrofuran / -20 °C

2: 90 percent / MeI-CaCO₃ / acetonitrile; H₂O

3: 89 percent Spectr_. / LiAlH(OtBu)3-LiI / diethyl ether / 1 h / 0 °C

4: iPr₂EtN / CH₂Cl₂ / 0 °C

With n-butyllithium; MeI-CaCO₃; lithium tri-t-butoxyaluminum hydride; N-ethyl-N,N-diisopropylamine; lithium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(00)99366-3