3-cyclohexyl-6-{[3-(4-fluoro-2-(trifluoromethyl)phenyl)isoxazol-5-yl]methyl}-2-phenyl-6H-pyrrolo[2,3-c]pyridine

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Chemical Name:3-cyclohexyl-6-{[3-(4-fluoro-2-(trifluoromethyl)phenyl)isoxazol-5-yl]methyl}-2-phenyl-6H-pyrrolo[2,3-c]pyridine
CAS No.:1049768-32-2
Molecular Formula:C₃₀H₂₅F₄N₃O
Molecular Weight:519.542
Hs Code.:

Synonyms:3-cyclohexyl-6-{[3-(4-fluoro-2-(trifluoromethyl)phenyl)isoxazol-5-yl]methyl}-2-phenyl-6H-pyrrolo[2,3-c]pyridine

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Chemical Property of 3-cyclohexyl-6-{[3-(4-fluoro-2-(trifluoromethyl)phenyl)isoxazol-5-yl]methyl}-2-phenyl-6H-pyrrolo[2,3-c]pyridine

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Technology Process of 3-cyclohexyl-6-{[3-(4-fluoro-2-(trifluoromethyl)phenyl)isoxazol-5-yl]methyl}-2-phenyl-6H-pyrrolo[2,3-c]pyridine

There total 5 articles about 3-cyclohexyl-6-{[3-(4-fluoro-2-(trifluoromethyl)phenyl)isoxazol-5-yl]methyl}-2-phenyl-6H-pyrrolo[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 858939-35-2
5-chloromethyl-3-(4-fluoro-2-trifluoromethyl-phenyl)-isoxazole

: 1049768-43-5
3-cyclohexyl-2-phenyl-1H-pyrrolo[2,3-c]pyridine

: 1049768-32-2
3-cyclohexyl-6-{[3-(4-fluoro-2-(trifluoromethyl)phenyl)isoxazol-5-yl]methyl}-2-phenyl-6H-pyrrolo[2,3-c]pyridine

Guidance literature:: With sodium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 12h; Alkaline aqueous solution;

Reference yield:

: 148991-61-1
triethylsilyl(cyclohexylethynyl)silane

: 1049768-32-2
3-cyclohexyl-6-{[3-(4-fluoro-2-(trifluoromethyl)phenyl)isoxazol-5-yl]methyl}-2-phenyl-6H-pyrrolo[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; lithium chloride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 24 h / 100 °C

2: trifluorormethanesulfonic acid; [bis(pyridine)iodine]⁺ tetrafluoroborate / dichloromethane / 1.5 h / 20 °C

3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol; water; toluene / 12 h / 90 °C

4: sodium hydroxide / water; N,N-dimethyl-formamide / 12 h / 20 °C / Alkaline aqueous solution

With sodium hydroxide; trifluorormethanesulfonic acid; sodium carbonate; [bis(pyridine)iodine]⁺ tetrafluoroborate; lithium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 105752-11-2
4-iodopyridin-3-amine

: 1049768-32-2
3-cyclohexyl-6-{[3-(4-fluoro-2-(trifluoromethyl)phenyl)isoxazol-5-yl]methyl}-2-phenyl-6H-pyrrolo[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; lithium chloride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 24 h / 100 °C

2: trifluorormethanesulfonic acid; [bis(pyridine)iodine]⁺ tetrafluoroborate / dichloromethane / 1.5 h / 20 °C

3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol; water; toluene / 12 h / 90 °C

4: sodium hydroxide / water; N,N-dimethyl-formamide / 12 h / 20 °C / Alkaline aqueous solution

With sodium hydroxide; trifluorormethanesulfonic acid; sodium carbonate; [bis(pyridine)iodine]⁺ tetrafluoroborate; lithium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;