(2R)-3-(benzo[b]thiophen-3-yl)-2-(5-((4-butylphenyl)ethynyl)thiophene-2-sulfonamido)-N-hydroxypropanamide

Base Information

Chemical Name:(2R)-3-(benzo[b]thiophen-3-yl)-2-(5-((4-butylphenyl)ethynyl)thiophene-2-sulfonamido)-N-hydroxypropanamide
CAS No.:1312952-34-3
Molecular Formula:C₂₇H₂₆N₂O₄S₃
Molecular Weight:538.712
Hs Code.:

Synonyms:(2R)-3-(benzo[b]thiophen-3-yl)-2-(5-((4-butylphenyl)ethynyl)thiophene-2-sulfonamido)-N-hydroxypropanamide

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Chemical Property of (2R)-3-(benzo[b]thiophen-3-yl)-2-(5-((4-butylphenyl)ethynyl)thiophene-2-sulfonamido)-N-hydroxypropanamide

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Technology Process of (2R)-3-(benzo[b]thiophen-3-yl)-2-(5-((4-butylphenyl)ethynyl)thiophene-2-sulfonamido)-N-hydroxypropanamide

There total 4 articles about (2R)-3-(benzo[b]thiophen-3-yl)-2-(5-((4-butylphenyl)ethynyl)thiophene-2-sulfonamido)-N-hydroxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1312952-42-3
(2R)-3-(benzo[b]thiophen-3-yl)-2-(5-((4-butylphenyl)ethynyl)thiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

: 1312952-34-3
(2R)-3-(benzo[b]thiophen-3-yl)-2-(5-((4-butylphenyl)ethynyl)thiophene-2-sulfonamido)-N-hydroxypropanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; water; for 0.5h;
DOI:10.1016/j.ejmech.2011.03.033

Reference yield:

: 111139-55-0
(R)-2-amino-3-<1>benzothiophene-3-ylpropionic acid

: 1312952-34-3
(2R)-3-(benzo[b]thiophen-3-yl)-2-(5-((4-butylphenyl)ethynyl)thiophene-2-sulfonamido)-N-hydroxypropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 1,4-dioxane; water / 20 °C

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / Inert atmosphere

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine / tetrahydrofuran / 0.17 h / 60 °C / Microwave irradiation

4: hydrogenchloride / 1,4-dioxane; methanol; water / 0.5 h

With 4-methyl-morpholine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 3: Sonogashira reaction;
DOI:10.1016/j.ejmech.2011.03.033

Reference yield:

: 1312952-36-5
(R)-3-(benzo[b]thiophen-3-yl)-2-(5-bromothiophene-2-sulfonamido)propanoic acid

: 1312952-34-3
(2R)-3-(benzo[b]thiophen-3-yl)-2-(5-((4-butylphenyl)ethynyl)thiophene-2-sulfonamido)-N-hydroxypropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine / tetrahydrofuran / 0.17 h / 60 °C / Microwave irradiation

3: hydrogenchloride / 1,4-dioxane; methanol; water / 0.5 h

With 4-methyl-morpholine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 2: Sonogashira reaction;
DOI:10.1016/j.ejmech.2011.03.033