1-Benzoyl-1,7-diazaspiro[4.4]nonan-6-one

Base Information

Chemical Name:1-Benzoyl-1,7-diazaspiro[4.4]nonan-6-one
CAS No.:128244-00-8
Molecular Formula:C14H16 N2 O2
Molecular Weight:244.293
Hs Code.:2933990090
DSSTox Substance ID:DTXSID10576069
Mol file:128244-00-8.mol

Synonyms:1-Benzoyl-1,7-diazaspiro[4.4]nonan-6-one;128244-00-8;1,7-Diazaspiro[4.4]nonan-6-one, 1-benzoyl-;1,7-Diazasprio[4.4]nonan-6-one, 1-benzoyl;1,7-Diazaspiro[4.4]nonan-6-one,1-benzoyl-;SCHEMBL1762490;DTXSID10576069;OIQRTEVAOMPNDH-UHFFFAOYSA-N;AKOS016013006;AM807659;1,7-Diazasprio[4.4]nonan-6-one,1-benzoyl;CS-0000897;F81224;A849115;1-(phenylcarbonyl)-1,7-diazaspiro[4.4]nonan-6-one

Suppliers and Price of 1-Benzoyl-1,7-diazaspiro[4.4]nonan-6-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-Benzoyl-1,7-diazaspiro[4.4]nonan-6-one 95+%
1g
$ 772.00

Chemenu
1-benzoyl-1,7-diazaspiro[4.4]nonan-6-one 95%
1g
$ 729.00

American Custom Chemicals Corporation
1,7-DIAZASPRIO[4.4]NONAN-6-ONE, 1-BENZOYL 95.00%
5MG
$ 499.39

Alichem
1-Benzoyl-1,7-diazaspiro[4.4]nonan-6-one
1g
$ 678.24

Total 9 raw suppliers

Chemical Property of 1-Benzoyl-1,7-diazaspiro[4.4]nonan-6-one

Chemical Property:

Vapor Pressure:2.83E-10mmHg at 25°C
Boiling Point:503.8°Cat760mmHg
Flash Point:258.5°C
PSA：49.41000
Density:1.26g/cm³
LogP:1.44800
Storage Temp.:2-8°C
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:244.121177757
Heavy Atom Count:18
Complexity:363

Purity/Quality:

97% ^*data from raw suppliers

1-Benzoyl-1,7-diazaspiro[4.4]nonan-6-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2(CCNC2=O)N(C1)C(=O)C3=CC=CC=C3

Technology Process of 1-Benzoyl-1,7-diazaspiro[4.4]nonan-6-one

There total 5 articles about 1-Benzoyl-1,7-diazaspiro[4.4]nonan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.3%

: 128243-98-1
methyl 1-benzoyl-2-(nitrilomethyl)pyrrolidine-2-carboxylate

: 128244-00-8
1-benzoyl-1,7-diazaspiro<4.4>nonan-6-one

Guidance literature:: methyl 1-benzoyl-2-(nitrilomethyl)pyrrolidine-2-carboxylate; With sulfuric acid; In methanol; Cooling with ice;

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 23h; under 2585.81 Torr; Inert atmosphere;

With sodium hydrogencarbonate; potassium carbonate; In water; pH=9 - 10; Reflux;

Reference yield:

: 5493-38-9
N-benzoyl-L-proline methyl ester

: 128244-00-8
1-benzoyl-1,7-diazaspiro<4.4>nonan-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, N,N,N',N'-tetramethylenediamine / 1.) THF, hexanes, -75 deg C, 10 min, 2.) a.) -78 deg C, 1 h, b.) from -78 deg C to 0 deg C

2: H₂ / Raney nickel / methanol; tetrahydrofuran / 46 h / 50 °C / 2585.7 Torr

3: toluene / 48 h / Heating

With N,N,N,N,-tetramethylethylenediamine; hydrogen; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm00170a035

Reference yield:

: 5874-58-8
N-(benzoyl)-L-proline

: 128244-00-8
1-benzoyl-1,7-diazaspiro<4.4>nonan-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / thionyl chloride / 1.) 0 deg C, 1 h, 2.) RT, overnight

2: 1.) LDA, N,N,N',N'-tetramethylenediamine / 1.) THF, hexanes, -75 deg C, 10 min, 2.) a.) -78 deg C, 1 h, b.) from -78 deg C to 0 deg C

3: H₂ / Raney nickel / methanol; tetrahydrofuran / 46 h / 50 °C / 2585.7 Torr

4: toluene / 48 h / Heating

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; hydrogen; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm00170a035