2-(3,4-difluorophenyl)acetaldehyde

Base Information

• Chemical Name: 2-(3,4-difluorophenyl)acetaldehyde
• CAS No.: 109346-84-1
• Molecular Formula: C₈H₆F₂O
• Molecular Weight: 156.132
• Mol file: 109346-84-1.mol

Synonyms:2-(3,4-difluorophenyl)acetaldehyde

Chemical Property of 2-(3,4-difluorophenyl)acetaldehyde

Chemical Property:

• Boiling Point: 204.0±25.0 °C(Predicted)
• Density: 1.219±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

(3,4-Difluorophenyl)acetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-difluorophenyl)acetaldehyde

There total 6 articles about 2-(3,4-difluorophenyl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(3,4-difluorophenyl)acetic acid (658-93-5) → 2-chloro-2-(3,4-difluorophenyl)acetaldehyde + C8H4Cl2F2O + 2-(3,4-difluorophenyl)acetaldehyde (109346-84-1)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.9b03172

Reference yield:

1,2-difluoro-4-(2-methoxy-vinyl)-benzene (872046-03-2) → 2-(3,4-difluorophenyl)acetaldehyde (109346-84-1)

Guidance literature:

With hydrogenchloride; In water; acetone; at 45 ℃; for 4h;

Reference yield:

2-(3,4-difluorophenyl)ethan-1-ol (286440-92-4) → 2-(3,4-difluorophenyl)acetaldehyde (109346-84-1)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In acetonitrile; at 80 ℃; for 2h;

upstream raw materials:

1,2-difluoro-4-(2-methoxy-vinyl)-benzene

1-methoxy-2-(3,4-difluorophenyl)ethane

ethyl 2-(3,4-difluorophenyl)acetate

(3,4-difluorophenyl)acetic acid

Refernces

• 1、 An, Hongchan,Lee, Seungbeom,Lee, Jung Min,Jo, Dong Hyun,Kim, Joohwan,Jeong, Yoo-Seong,Heo, Mi Jeong,Cho, Chang Sik,Choi, Hoon,Seo, Ji Hae,Hwang, Seyeon,Lim, Jihye,Kim, Taewoo,Jun, Hyoung Oh,Sim, Jaehoon,Lim, Changjin,Hur, Joonseong,Ahn, Jungmin,Kim, Hyun Su,Seo, Seung-Yong,Na, Younghwa,Kim, Seok-Ho,Lee, Jeewoo,Lee, Jeeyeon,Chung, Suk-Jae,Kim, Young-Myeong,Kim, Kyu-Won,Kim, Sang Geon,Kim, Jeong Hun,Suh, Young-Ger. "Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy". . p. 9266 - 9286. Retrieved 2018/10/24.
• 2、 -. "NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS". Page/Page column 88. . Retrieved 2010/11/27.