N-ethyl-5-((2-fluorophenyl)(hydroxy)methyl)-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide

Base Information

Chemical Name:N-ethyl-5-((2-fluorophenyl)(hydroxy)methyl)-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide
CAS No.:1608112-46-4
Molecular Formula:C₂₃H₂₄FNO₆
Molecular Weight:429.445
Hs Code.:

Synonyms:N-ethyl-5-((2-fluorophenyl)(hydroxy)methyl)-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-ethyl-5-((2-fluorophenyl)(hydroxy)methyl)-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide

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Technology Process of N-ethyl-5-((2-fluorophenyl)(hydroxy)methyl)-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide

There total 3 articles about N-ethyl-5-((2-fluorophenyl)(hydroxy)methyl)-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1608112-72-6
N-ethyl-5-(2-fluorobenzoyl)-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide

: 1608112-46-4
N-ethyl-5-((2-fluorophenyl)(hydroxy)methyl)-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/ejoc.201301238 DOI:10.1002/ejoc.201301238

Reference yield:

: 222162-06-3
5-(2-fluorobenzoyl)furan-2-carboxylic acid

: 1608112-46-4
N-ethyl-5-((2-fluorophenyl)(hydroxy)methyl)-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 3 h / Reflux; Inert atmosphere

2: triethylamine / Inert atmosphere

3: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; triethylamine; In methanol;
DOI:10.1002/ejoc.201301238

Reference yield:

: 163629-15-0
N-ethyl-3,4,5-trimethoxyaniline

: 1608112-46-4
N-ethyl-5-((2-fluorophenyl)(hydroxy)methyl)-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / Inert atmosphere

2: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; triethylamine; In methanol;
DOI:10.1002/ejoc.201301238