2-carbamoyl-3-(4-chloro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Base Information

Chemical Name:2-carbamoyl-3-(4-chloro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester
CAS No.:910641-84-8
Molecular Formula:C₁₆H₁₈ClNO₅
Molecular Weight:339.776
Hs Code.:

Synonyms:2-carbamoyl-3-(4-chloro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

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Chemical Property of 2-carbamoyl-3-(4-chloro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

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Technology Process of 2-carbamoyl-3-(4-chloro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

There total 3 articles about 2-carbamoyl-3-(4-chloro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 910641-58-6
3-(4-chloro-phenyl)-2-cyano-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

: 910641-84-8
2-carbamoyl-3-(4-chloro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: With sulfuric acid; trifluoroacetic acid; at 20 ℃; for 4h;
DOI:10.1016/j.tet.2006.06.099

Reference yield:

: 131469-72-2
methyl 3-acetoxy-3-(4-chlorophenyl)-2-methylenepropanoate

: 910641-84-8
2-carbamoyl-3-(4-chloro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: DABCO / tetrahydrofuran; H₂O / 0.33 h / 20 °C

1.2: 76 percent / tetrahydrofuran; H₂O / 2 h / 20 °C

2.1: 89 percent / TFA; H₂SO₄ / 4 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sulfuric acid; trifluoroacetic acid; In tetrahydrofuran; water;
DOI:10.1016/j.tet.2006.06.099

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 910641-84-8
2-carbamoyl-3-(4-chloro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: DABCO / tetrahydrofuran; H₂O / 0.33 h / 20 °C

1.2: 76 percent / tetrahydrofuran; H₂O / 2 h / 20 °C

2.1: 89 percent / TFA; H₂SO₄ / 4 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sulfuric acid; trifluoroacetic acid; In tetrahydrofuran; water;
DOI:10.1016/j.tet.2006.06.099