tert-butyl 4-{2-[3,5-dichloro-6-{[(3-chloro-2-methylphenyl)(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoate

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Chemical Name:tert-butyl 4-{2-[3,5-dichloro-6-{[(3-chloro-2-methylphenyl)(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoate
CAS No.:1201818-38-3
Molecular Formula:C₂₇H₂₉Cl₃N₂O₃
Molecular Weight:535.898
Hs Code.:

Synonyms:tert-butyl 4-{2-[3,5-dichloro-6-{[(3-chloro-2-methylphenyl)(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoate

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Chemical Property of tert-butyl 4-{2-[3,5-dichloro-6-{[(3-chloro-2-methylphenyl)(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoate

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Technology Process of tert-butyl 4-{2-[3,5-dichloro-6-{[(3-chloro-2-methylphenyl)(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoate

There total 13 articles about tert-butyl 4-{2-[3,5-dichloro-6-{[(3-chloro-2-methylphenyl)(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1091599-69-7
tert-butyl 4-{2-[6-(bromomethyl)-3,5-dichloro-2-oxopyridin-1(2H)-yl]ethyl}benzoate

: 957062-82-7
3-chloro-N,2-dimethylaniline monohydrochloride

: 1201818-38-3
tert-butyl 4-{2-[3,5-dichloro-6-{[(3-chloro-2-methylphenyl)(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoate

Guidance literature:: tert-butyl 4-{2-[6-(bromomethyl)-3,5-dichloro-2-oxopyridin-1(2H)-yl]ethyl}benzoate; 3-chloro-N,2-dimethylaniline monohydrochloride; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 70 ℃;

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 70 ℃; for 5h;

Reference yield:

: 675-10-5
4-hydroxy-6-methyl-2-pyron

: 1201818-38-3
tert-butyl 4-{2-[3,5-dichloro-6-{[(3-chloro-2-methylphenyl)(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / water / 0.25 h / 20 °C

1.2: 24 h / 80 °C

1.3: 0.5 h

2.1: sulfuric acid / 4 h / Heating; Reflux

3.1: pyridine / 3 h / 5 °C

4.1: hydrogen; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethyl acetate; water

5.1: N-chloro-succinimide; acetic acid / water / 20 - 70 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 70 °C

7.1: dmap / tetrahydrofuran / 60 °C

8.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

9.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 70 °C

9.2: 5 h / 70 °C

With pyridine; dmap; N-chloro-succinimide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; water; ethyl acetate;

Reference yield:

: 1091599-88-0
methyl 4-{2-[6-methyl-2-oxo-4-{[(trifluoromethyl)sulfonyl]oxy}pyridin-1(2H)-yl]ethyl}benzoate

: 1201818-38-3
tert-butyl 4-{2-[3,5-dichloro-6-{[(3-chloro-2-methylphenyl)(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethyl acetate; water

2.1: N-chloro-succinimide; acetic acid / water / 20 - 70 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 70 °C

4.1: dmap / tetrahydrofuran / 60 °C

5.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 70 °C

6.2: 5 h / 70 °C

With dmap; N-chloro-succinimide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; water; ethyl acetate;