1-(5-fluoropyrimidin-4-yl)ethyl-4-methyl benzenesulfonate

Base Information

• Chemical Name: 1-(5-fluoropyrimidin-4-yl)ethyl-4-methyl benzenesulfonate
• CAS No.: 1289559-67-6
• Molecular Formula: C₁₃H₁₃FN₂O₃S
• Molecular Weight: 296.322
• Mol file: 1289559-67-6.mol

Synonyms:1-(5-fluoropyrimidin-4-yl)ethyl-4-methyl benzenesulfonate

Chemical Property of 1-(5-fluoropyrimidin-4-yl)ethyl-4-methyl benzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-fluoropyrimidin-4-yl)ethyl-4-methyl benzenesulfonate

There total 3 articles about 1-(5-fluoropyrimidin-4-yl)ethyl-4-methyl benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(5-fluoropyrimidin-4-yl)ethanol (1289559-66-5) + p-toluenesulfonyl chloride (98-59-9) → 1-(5-fluoropyrimidin-4-yl)ethyl-4-methyl benzenesulfonate (1289559-67-6)

Guidance literature:

With triethylamine; dmap; In dichloromethane; at 20 - 30 ℃;

Reference yield:

C6H5FN2O (1289559-75-6) → 1-(5-fluoropyrimidin-4-yl)ethyl-4-methyl benzenesulfonate (1289559-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 5 h

2: triethylamine / dmap / dichloromethane / 20 - 30 °C

With sodium tetrahydroborate; triethylamine; dmap; In ethanol; dichloromethane;

Reference yield:

1-(2,6-dichloro-5-fluoropyrimidin-4-yl)ethanone (1289559-65-4) → 1-(5-fluoropyrimidin-4-yl)ethyl-4-methyl benzenesulfonate (1289559-67-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; sodium acetate / palladium on activated carbon / ethanol / 25 °C

2: sodium tetrahydroborate / ethanol / 5 h

3: triethylamine / dmap / dichloromethane / 20 - 30 °C

With sodium tetrahydroborate; hydrogen; sodium acetate; triethylamine; dmap; palladium on activated carbon; In ethanol; dichloromethane;

upstream raw materials:

1-(5-fluoropyrimidin-4-yl)ethanol

p-toluenesulfonyl chloride

C₆H₅FN₂O

1-(2,6-dichloro-5-fluoropyrimidin-4-yl)ethanone

Downstream raw materials:

2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol