(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-butyl-4-methylpentanamide lithium

Base Information

Chemical Name:(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-butyl-4-methylpentanamide lithium
CAS No.:1583283-13-9
Molecular Formula:C₁₉H₃₁N₃O₅P*Li
Molecular Weight:419.387
Hs Code.:

Synonyms:(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-butyl-4-methylpentanamide lithium

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Chemical Property of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-butyl-4-methylpentanamide lithium

Chemical Property:

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Technology Process of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-butyl-4-methylpentanamide lithium

There total 9 articles about (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-butyl-4-methylpentanamide lithium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1583283-60-6
C₂₀H₃₄N₃O₅P

: 1583283-13-9
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-butyl-4-methylpentanamide lithium

Guidance literature:: With lithium hydroxide; In water; acetonitrile;
DOI:10.1021/jm401609a

Reference yield:

: 621-84-1
O-benzyl carbamate

: 1583283-13-9
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-butyl-4-methylpentanamide lithium

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate; water / water / 20 °C

2: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: 3 h / Reflux

4: sodium hydroxide / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C

6: lithium hydroxide / water; acetonitrile

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm401609a

Reference yield:

: 31037-42-0
hydroxymethyl carbamic acid benzyl ester

: 1583283-13-9
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-butyl-4-methylpentanamide lithium

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2: 3 h / Reflux

3: sodium hydroxide / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C

5: lithium hydroxide / water; acetonitrile

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm401609a