6,6'-bis{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-N,N,N',N'-tetraethyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide

Base Information

Chemical Name:6,6'-bis{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-N,N,N',N'-tetraethyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide
CAS No.:1285535-45-6
Molecular Formula:C₄₀H₄₂Cl₂F₂N₄O₈
Molecular Weight:815.698
Hs Code.:

Synonyms:6,6'-bis{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-N,N,N',N'-tetraethyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide

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Chemical Property of 6,6'-bis{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-N,N,N',N'-tetraethyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide

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Technology Process of 6,6'-bis{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-N,N,N',N'-tetraethyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide

There total 7 articles about 6,6'-bis{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-N,N,N',N'-tetraethyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1285535-51-4
C₂₄H₃₂N₂O₆

: 96980-64-2
N-(2-chloroacetyl)-3-chloro-4-fluoroaniline

: 1285535-45-6
6,6'-bis{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-N,N,N',N'-tetraethyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide

Guidance literature:: C₂₄H₃₂N₂O₆; With potassium carbonate; In ethanol; at 20 ℃; for 0.5h;

N-(2-chloroacetyl)-3-chloro-4-fluoroaniline; In ethanol; for 10h; Reflux;
DOI:10.2174/157340611796150914

Reference yield:

: 1285535-49-0
C₁₉H₂₂BrNO₃

: 1285535-45-6
6,6'-bis{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-N,N,N',N'-tetraethyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper / N,N-dimethyl-formamide / 4 h / Inert atmosphere; Reflux

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3.1: potassium carbonate / ethanol / 0.5 h / 20 °C

3.2: 10 h / Reflux

With palladium 10% on activated carbon; hydrogen; copper; potassium carbonate; In methanol; ethanol; N,N-dimethyl-formamide; 1.1: Ullmann condensation;
DOI:10.2174/157340611796150914

Reference yield:

: 1233979-40-2
C₁₅H₁₂BrClO₃

: 1285535-45-6
6,6'-bis{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-N,N,N',N'-tetraethyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; dichloromethane / 2 h / 20 °C / Cooling with ice

2.1: copper / N,N-dimethyl-formamide / 4 h / Inert atmosphere; Reflux

3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

4.1: potassium carbonate / ethanol / 0.5 h / 20 °C

4.2: 10 h / Reflux

With palladium 10% on activated carbon; hydrogen; copper; potassium carbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 2.1: Ullmann condensation;
DOI:10.2174/157340611796150914