(S)-N²-[1-(4-fluorophenyl)ethyl]-4-[1-(methanesulfonylhalide)piperidin-4-yl]-N⁶-(aminopyrazine-2-yl)-2,6-dimamine

Base Information

• Chemical Name: (S)-N²-[1-(4-fluorophenyl)ethyl]-4-[1-(methanesulfonylhalide)piperidin-4-yl]-N⁶-(aminopyrazine-2-yl)-2,6-dimamine
• CAS No.: 1239362-67-4
• Molecular Formula: C₂₃H₂₇FN₆O₂S
• Molecular Weight: 470.571

Synonyms:(S)-N²-[1-(4-fluorophenyl)ethyl]-4-[1-(methanesulfonylhalide)piperidin-4-yl]-N⁶-(aminopyrazine-2-yl)-2,6-dimamine

Chemical Property of (S)-N²-[1-(4-fluorophenyl)ethyl]-4-[1-(methanesulfonylhalide)piperidin-4-yl]-N⁶-(aminopyrazine-2-yl)-2,6-dimamine

Chemical Property:

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Technology Process of (S)-N²-[1-(4-fluorophenyl)ethyl]-4-[1-(methanesulfonylhalide)piperidin-4-yl]-N⁶-(aminopyrazine-2-yl)-2,6-dimamine

There total 6 articles about (S)-N²-[1-(4-fluorophenyl)ethyl]-4-[1-(methanesulfonylhalide)piperidin-4-yl]-N⁶-(aminopyrazine-2-yl)-2,6-dimamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N2-[1-(4-Fluorophenyl)ethyl]-4-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-N6-(pyrazin-2-yl)pyridine-2,6-diamine (1239363-39-3) → (S)-N2-[1-(4-fluorophenyl)ethyl]-4-[1-(methanesulfonylhalide)piperidin-4-yl]-N6-(aminopyrazine-2-yl)-2,6-dimamine (1239362-67-4)

Guidance literature:

With ammonium formate; 20% palladium hydroxide-activated charcoal; In methanol; for 5h; Reflux;

Reference yield:

(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]pyridine-2-amine (1239363-38-2) → (S)-N2-[1-(4-fluorophenyl)ethyl]-4-[1-(methanesulfonylhalide)piperidin-4-yl]-N6-(aminopyrazine-2-yl)-2,6-dimamine (1239362-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium t-butanolate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 5 h / 100 °C / Inert atmosphere

2: ammonium formate / 20% palladium hydroxide-activated charcoal / methanol / 5 h / Reflux

With ammonium formate; sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; In methanol; toluene;

Reference yield:

2,6-dichloro-4-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]pyridine (1239363-37-1) → (S)-N2-[1-(4-fluorophenyl)ethyl]-4-[1-(methanesulfonylhalide)piperidin-4-yl]-N6-(aminopyrazine-2-yl)-2,6-dimamine (1239362-67-4)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / tetrahydrofuran / 10 h / 60 °C / Inert atmosphere

2: sodium t-butanolate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 5 h / 100 °C / Inert atmosphere

3: ammonium formate / 20% palladium hydroxide-activated charcoal / methanol / 5 h / Reflux

With ammonium formate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; palladium diacetate; In tetrahydrofuran; methanol; toluene;

upstream raw materials:

2,6-dichloro-4-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]pyridine

(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]pyridine-2-amine

4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

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