β-hydroxy-β-(2-methoxyphenyl)-2-methoxybenzenepropanenitrile

Base Information

Chemical Name:β-hydroxy-β-(2-methoxyphenyl)-2-methoxybenzenepropanenitrile
CAS No.:120553-98-2
Molecular Formula:C₁₇H₁₇NO₃
Molecular Weight:283.327
Hs Code.:

Synonyms:β-hydroxy-β-(2-methoxyphenyl)-2-methoxybenzenepropanenitrile

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Chemical Property of β-hydroxy-β-(2-methoxyphenyl)-2-methoxybenzenepropanenitrile

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Technology Process of β-hydroxy-β-(2-methoxyphenyl)-2-methoxybenzenepropanenitrile

There total 1 articles about β-hydroxy-β-(2-methoxyphenyl)-2-methoxybenzenepropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13102-33-5
2,2'-dimethoxybenzophenone

: 75-05-8,26809-02-9
acetonitrile

: 120553-98-2
β-hydroxy-β-(2-methoxyphenyl)-2-methoxybenzenepropanenitrile

Guidance literature:: With n-butyllithium; diisopropylamine; Yield given. Multistep reaction; 1.) THF, hexane, -70 deg C, 5 min, 2.) THF, -70 -> -35 deg C, 15 min;
DOI:10.1021/jm00128a026

Reference yield: 71.5%

: 120553-98-2
β-hydroxy-β-(2-methoxyphenyl)-2-methoxybenzenepropanenitrile

: 120553-99-3
3,3-bis(2-methoxyphenyl)-2-propenenitrile

Guidance literature:: With pyridine; thionyl chloride; for 2h; Ambient temperature;
DOI:10.1021/jm00128a026

Reference yield:

: 120553-98-2
β-hydroxy-β-(2-methoxyphenyl)-2-methoxybenzenepropanenitrile

: (E)-5,5-bis (2-methoxyphenyl)-N-[4-(3-pyridinyl) butyl]-2,4-pentadienamide

Guidance literature:: Multi-step reaction with 5 steps

1: 71.5 percent / SOCl₂, pyridine / 2 h / Ambient temperature

2: 1.) DIBAH, 2.) 5percent H₂SO₄ / 1.) toluene, hexane, a) -40 deg C, 1 h, b) -40 -> -12 deg C, 1 h, 2.) a) -10 deg C, b) 40 deg C, 2.5 h

3: 2.) NaOH / 1.) CH₂Cl₂, room temperature, 3 d, 2.) MeOH, H₂O, reflux, 30 min

4: 88 percent / DCC / CH₂Cl₂ / 1.) 0-5 deg C, 60 min, 2.) room temperature, overnight

5: 81 percent / tetrahydrofuran / 1.) room temperature, overnight, 2.) reflux, 3 h

With pyridine; sodium hydroxide; thionyl chloride; sulfuric acid; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00128a026