Thiophosphoric acid O-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2,4-dichloro-phenyl) ester S-p-tolyl ester

Base Information

• Chemical Name: Thiophosphoric acid O-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2,4-dichloro-phenyl) ester S-p-tolyl ester
• CAS No.: 80973-41-7
• Molecular Formula: C₂₉H₃₇Cl₂N₂O₇PSSi
• Molecular Weight: 687.653
• Mol file: 80973-41-7.mol

Synonyms:Thiophosphoric acid O-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2,4-dichloro-phenyl) ester S-p-tolyl ester

Chemical Property of Thiophosphoric acid O-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2,4-dichloro-phenyl) ester S-p-tolyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiophosphoric acid O-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2,4-dichloro-phenyl) ester S-p-tolyl ester

There total 3 articles about Thiophosphoric acid O-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2,4-dichloro-phenyl) ester S-p-tolyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester (80973-42-8) + para-thiocresol (106-45-6) → Thiophosphoric acid O-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2,4-dichloro-phenyl) ester S-p-tolyl ester (80973-41-7)

Guidance literature:

With 1-methyl-1H-imidazole; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1246/cl.1981.1725

Reference yield:

Phosphoric acid dibenzotriazol-1-yl ester 2,4-dichloro-phenyl ester (82410-50-2) → Thiophosphoric acid O-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2,4-dichloro-phenyl) ester S-p-tolyl ester (80973-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran

2: 60 percent / N-methylimidazole / tetrahydrofuran / 2 h / 20 °C

With 1-methyl-1H-imidazole; In tetrahydrofuran;

DOI:10.1246/cl.1981.1725

Reference yield:

5'-tert-butyldimethylsilyloxy-2'-deoxythymidine (40733-28-6) → Thiophosphoric acid O-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2,4-dichloro-phenyl) ester S-p-tolyl ester (80973-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran

2: 60 percent / N-methylimidazole / tetrahydrofuran / 2 h / 20 °C

With 1-methyl-1H-imidazole; In tetrahydrofuran;

DOI:10.1246/cl.1981.1725

upstream raw materials:

Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,4-dichloro-phenyl ester

para-thiocresol

Phosphoric acid dibenzotriazol-1-yl ester 2,4-dichloro-phenyl ester

5'-tert-butyldimethylsilyloxy-2'-deoxythymidine