methyl 3-<1-(4-chlorobenzyl)-7-hydroxy-1,4,5,6-tetrahydrothiepino<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Base Information

Chemical Name:methyl 3-<1-(4-chlorobenzyl)-7-hydroxy-1,4,5,6-tetrahydrothiepino<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate
CAS No.:147937-21-1
Molecular Formula:C₂₄H₂₆ClNO₃S
Molecular Weight:443.994
Hs Code.:

Synonyms:methyl 3-<1-(4-chlorobenzyl)-7-hydroxy-1,4,5,6-tetrahydrothiepino<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

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Chemical Property of methyl 3-<1-(4-chlorobenzyl)-7-hydroxy-1,4,5,6-tetrahydrothiepino<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

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Technology Process of methyl 3-<1-(4-chlorobenzyl)-7-hydroxy-1,4,5,6-tetrahydrothiepino<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

There total 7 articles about methyl 3-<1-(4-chlorobenzyl)-7-hydroxy-1,4,5,6-tetrahydrothiepino<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 147937-20-0
methyl 3-<1-(4-chlorobenzyl)-7-hydroxy-1,4-dihydrothiepino<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

: 147937-21-1
methyl 3-<1-(4-chlorobenzyl)-7-hydroxy-1,4,5,6-tetrahydrothiepino<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 16h; under 2068.6 Torr;
DOI:10.1021/jm00071a008

Reference yield:

: 20955-94-6
1-[(4-chlorophenyl)methyl]-1-(4-methoxyphenyl)-hydrazine hydrochloride

: 147937-21-1
methyl 3-<1-(4-chlorobenzyl)-7-hydroxy-1,4,5,6-tetrahydrothiepino<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / NaOAc, glacial AcOH / toluene / 72 h / Ambient temperature

2: ethanethiol, AlCl₃ / CH₂Cl₂ / 0.67 h / 25 °C

3: diethyl ether

4: dimethylformamide / 1 h / 0 °C

5: HCl gas / diethyl ether / 0.5 h

6: 35 percent / H₂ / 10percent Pd/C / methanol / 16 h / 2068.6 Torr

With hydrogenchloride; aluminium trichloride; hydrogen; sodium acetate; acetic acid; ethanethiol; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00071a008

Reference yield:

: methyl 5-(t-butylthio)-2,2-dimethyl-4-oxopentanoate

: 147937-21-1
methyl 3-<1-(4-chlorobenzyl)-7-hydroxy-1,4,5,6-tetrahydrothiepino<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / NaOAc, glacial AcOH / toluene / 72 h / Ambient temperature

2: ethanethiol, AlCl₃ / CH₂Cl₂ / 0.67 h / 25 °C

3: diethyl ether

4: dimethylformamide / 1 h / 0 °C

5: HCl gas / diethyl ether / 0.5 h

6: 35 percent / H₂ / 10percent Pd/C / methanol / 16 h / 2068.6 Torr

With hydrogenchloride; aluminium trichloride; hydrogen; sodium acetate; acetic acid; ethanethiol; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00071a008