(3R,4R)-3-(2,5-dimethoxy-4-methylphenyl)-4-hydroxy-2,2,3-trimethylcyclopentanone

Base Information

Chemical Name:(3R,4R)-3-(2,5-dimethoxy-4-methylphenyl)-4-hydroxy-2,2,3-trimethylcyclopentanone
CAS No.:358978-68-4
Molecular Formula:C₁₇H₂₄O₄
Molecular Weight:292.375
Hs Code.:

Synonyms:(3R,4R)-3-(2,5-dimethoxy-4-methylphenyl)-4-hydroxy-2,2,3-trimethylcyclopentanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R)-3-(2,5-dimethoxy-4-methylphenyl)-4-hydroxy-2,2,3-trimethylcyclopentanone

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Technology Process of (3R,4R)-3-(2,5-dimethoxy-4-methylphenyl)-4-hydroxy-2,2,3-trimethylcyclopentanone

There total 4 articles about (3R,4R)-3-(2,5-dimethoxy-4-methylphenyl)-4-hydroxy-2,2,3-trimethylcyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 733001-87-1
(1S,4R,5S)-4-(2,5-dimethoxy-4-methylphenyl)-3,3,4-trimethyl-6-oxa-bicyclo[3.1.0]hexan-2-one

: 358978-68-4
(3R,4R)-3-(2,5-dimethoxy-4-methylphenyl)-4-hydroxy-2,2,3-trimethylcyclopentanone

Guidance literature:: (1S,4R,5S)-4-(2,5-dimethoxy-4-methylphenyl)-3,3,4-trimethyl-6-oxa-bicyclo[3.1.0]hexan-2-one; With sodium tetrahydroborate; diphenyl diselenide; acetic acid; In ethanol; at 20 ℃; for 1h;

With oxygen; In ethanol; ethyl acetate; for 0.0833333h;
DOI:10.1271/bbb.69.374

Reference yield: 42.0%

: 77-78-1
dimethyl sulfate

: 359701-26-1
(2R,4R,5R)-4,5-dihydro-5,8,10,10-tetramethyl-2,5-methano-benzo[b]oxepin-2,4,7(3H)-triol

: 358978-68-4
(3R,4R)-3-(2,5-dimethoxy-4-methylphenyl)-4-hydroxy-2,2,3-trimethylcyclopentanone

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In acetonitrile; at 20 ℃; for 4h;
DOI:10.1021/np000593r

Reference yield:

: 733001-90-6
(R)-4-(2,5-dimethoxy-4-methylphenyl)-2-methoxy-4,5,5-trimethylcyclopent-2-enone

: 358978-68-4
(3R,4R)-3-(2,5-dimethoxy-4-methylphenyl)-4-hydroxy-2,2,3-trimethylcyclopentanone

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / aq. H₂O₂; NaOH / methanol / 6.5 h / 60 °C

2: 68 percent / PhSeSePh; NaBH₄ / ethanol; acetic acid / 1 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide; dihydrogen peroxide; In methanol; ethanol; acetic acid;
DOI:10.1016/j.tetlet.2004.04.191