2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 885278-75-1
• Molecular Formula: C12H10BrNO2S
• Molecular Weight: 312.187
• Hs Code.: 2934100090
• Mol file: 885278-75-1.mol

Synonyms:2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;Ethyl 2-(4-bromophenyl)-1,3-thiazole-4-carboxylate;Ethyl 2-(4-bromophenyl)thiazole-4-carboxylate

Chemical Property of 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 9.33E-07mmHg at 25°C
• Melting Point: 89-91 °C
• Refractive Index: 1.602
• Boiling Point: 404.6 °C at 760 mmHg
• PKA: -0.42±0.10(Predicted)
• Flash Point: 198.5 °C
• PSA: 67.43000
• Density: 1.5 g/cm³
• LogP: 3.74930
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Bromo-phenyl)-thiazole-4-carboxylicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

There total 5 articles about 2-(4-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C12H12BrNO2S (1332708-73-2) → ethyl 2-(4-bromophenyl)-1,3-thiazole-4-carboxylate (885278-75-1)

Guidance literature:

With oxygen; copper diacetate; In N,N-dimethyl-formamide; at 120 ℃; for 12h; under 760.051 Torr; Molecular sieve;

DOI:10.1016/j.tet.2011.07.016

Reference yield: 91.0%

ethyl Bromopyruvate (70-23-5) + p-bromothiobanzamide (26197-93-3) → ethyl 2-(4-bromophenyl)-1,3-thiazole-4-carboxylate (885278-75-1)

Guidance literature:

ethyl Bromopyruvate; p-bromothiobanzamide; In ethanol; at 20 ℃; for 6h;

With sulfuric acid; at 20 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 81.0%

C12H12BrNO2S (1221437-19-9) → ethyl 2-(4-bromophenyl)-1,3-thiazole-4-carboxylate (885278-75-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Molecular sieve;

DOI:10.1016/j.tetlet.2010.01.091

upstream raw materials:

ethyl Bromopyruvate

p-bromothiobanzamide

C₁₂H₁₂BrNO₂S

C₁₂H₁₂BrNO₂S

Downstream raw materials:

2-(4-Bromophenyl)thiazole-4-carboxamide

2-(4-bromophenyl)thiazole-4-carbohydrazide

2-(4-bromophenyl)-1,3-thiazole-4-carboxylic acid

2-(4-bromophenyl)-4-hydroxymethylthiazole

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