(S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propionaldehyde

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Chemical Name:(S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propionaldehyde
CAS No.:333972-93-3
Molecular Formula:C₃₈H₅₂O₂Si
Molecular Weight:568.915
Hs Code.:
Mol file:333972-93-3.mol

(S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propionaldehyde

Synonyms:(S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propionaldehyde

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Chemical Property of (S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propionaldehyde Edit

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Technology Process of (S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propionaldehyde

There total 1 articles about (S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 53906-49-3
3β-ol-23,24-bisnor-chol-5-en-22-al hemihydrochloride

: 58479-61-1
tert-butylchlorodiphenylsilane

: 333972-93-3
(S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propionaldehyde

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;
DOI:10.1039/b007139k

Reference yield:

: 333972-93-3
(S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propionaldehyde

: tert-Butyl-[(3S,8S,9S,10R,13R,14S,17R)-17-((1R,4R)-4-ethyl-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: aq. NH₄Cl; Zn / tetrahydrofuran / 3 h / 0 °C

2.1: MgBr₂*OEt₂ / CH₂Cl₂ / 0.17 h / 20 °C

2.2: (n-Bu)3SnH; Et₃B / CH₂Cl₂; hexane / 1 h / 0 °C

3.1: 89 percent / CH₂Cl₂ / 15 h / 20 °C

4.1: 66 percent / (n-Bu)3SnH; AIBN / toluene / 1 h / 20 °C

5.1: 79 percent / diethyl ether; hexane / 2 h / 0 °C

6.1: 54 percent / pyridine; MsCl / 15 h / 0 °C

7.1: 72 percent / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 5.5 h / 20 °C

With pyridine; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; ammonium chloride; methanesulfonyl chloride; magnesium bromide; zinc; 10percent Pd/C; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; ethyl acetate; toluene; 1.1: Reformatsky reaction;
DOI:10.1039/b007139k