1-(4-AMINOPHENYL)-3-METHYL-3-AZETIDINOL

Base Information

• Chemical Name: 1-(4-AMINOPHENYL)-3-METHYL-3-AZETIDINOL
• CAS No.: 344405-83-0
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.234
• Mol file: 344405-83-0.mol

Synonyms:1-(4-aminophenyl)-3-methylazetidin-3-ol

Chemical Property of 1-(4-AMINOPHENYL)-3-METHYL-3-AZETIDINOL

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

1-(4-Aminophenyl)-3-methyl-3-azetidinol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-AMINOPHENYL)-3-METHYL-3-AZETIDINOL

There total 1 articles about 1-(4-AMINOPHENYL)-3-METHYL-3-AZETIDINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-(4-aminophenyl)-3-methylazetidin-3-ol (344405-83-0)

Guidance literature:

Reference yield:

2,4-dichloro-1,3,5-triazine (2831-66-5) + 1-(4-aminophenyl)-3-methylazetidin-3-ol (344405-83-0) → 1-(4-((4-chloro-1,3,5-triazin-2-yl)amino)phenyl)-3-methylazetidin-3-ol

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 0.283333h; Inert atmosphere;

Reference yield:

1-(4-aminophenyl)-3-methylazetidin-3-ol (344405-83-0) → (3R,4S)-tert-butyl 4-(2-cyano-4-(4-((4-(3-hydroxy-3-methylazetidin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)phenoxy)-3-fluoropiperidine-1-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.28 h / 0 °C / Inert atmosphere

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 150 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;

Refernces