(2R,5R)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>cytosine

Base Information

• Chemical Name: (2R,5R)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>cytosine
• CAS No.: 145985-98-4
• Molecular Formula: C₂₄H₂₉N₃O₃SSi
• Molecular Weight: 467.664

Synonyms:(2R,5R)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>cytosine

Chemical Property of (2R,5R)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>cytosine

Chemical Property:

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Technology Process of (2R,5R)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>cytosine

There total 14 articles about (2R,5R)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+/-)-cis-N-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine (131086-21-0,131086-22-1,134678-17-4,134680-32-3,136846-20-3,136891-12-8,139757-68-9,141434-39-1,146726-78-5) + tert-butylchlorodiphenylsilane (58479-61-1) → cis-2-<<(tert-butyldiphenylsilyl)oxy>methyl>-5-(cytosin-1'-yl)-1,3-oxathiolane (136831-90-8,137125-20-3,137125-21-4,145416-33-7,145985-97-3,145985-98-4,149819-22-7)

Guidance literature:

With pyridine; for 24h; Ambient temperature;

DOI:10.1080/07328319308019017

Reference yield: 80.0%

[2-[[tert-butyl(diphenyl)silyl]oxymethyl]-1,3-oxathiolan-5-yl] acetate (139757-72-5) → cis-2-<<(tert-butyldiphenylsilyl)oxy>methyl>-5-(cytosin-1'-yl)-1,3-oxathiolane (136831-90-8,137125-20-3,137125-21-4,145416-33-7,145985-97-3,145985-98-4,149819-22-7)

Guidance literature:

With tin(IV) chloride; In dichloromethane; Ambient temperature;

Reference yield: 76.0%

(2R,5R)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N4-acetylcytosine (139757-73-6) → (2R,5R)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>cytosine (145985-98-4)

Guidance literature:

With ammonia; for 3h; Ambient temperature;

DOI:10.1021/jm00054a001

upstream raw materials:

(+/-)-cis-N-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine

tert-butylchlorodiphenylsilane

[2-[[tert-butyl(diphenyl)silyl]oxymethyl]-1,3-oxathiolan-5-yl] acetate

cis/trans-2-benzoyloxymethyl-5-(cytosin-1'-yl)-1,3-oxathiolane

Downstream raw materials:

(+/-)-cis-N-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine

(+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine

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