2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carboximidamide

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Chemical Name:2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carboximidamide
CAS No.:1197338-60-5
Molecular Formula:C₂₃H₂₃N₇O₂
Molecular Weight:429.481
Hs Code.:

Synonyms:2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carboximidamide

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Chemical Property of 2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carboximidamide

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Technology Process of 2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carboximidamide

There total 8 articles about 2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₆N₆O₃*ClH

: 1197338-60-5
2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carboximidamide

Guidance literature:: With ammonia; In methanol; at 20 ℃;

Reference yield:

: 1197340-73-0
methyl 3-(4-bromophenyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazole-5-carboxylate

: 1197338-60-5
2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 120 °C / Microwave irradiation

2: lithium hydroxide monohydrate / methanol / 0.33 h / 120 °C / Microwave irradiation

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: acetic acid / 0.92 h / 150 °C / Microwave irradiation

5: trifluoroacetic acid / 0.5 h / 120 °C / Microwave irradiation

6: acetyl chloride / 20 °C / Cooling with ice bath

7: ammonia / methanol / 20 °C

With lithium hydroxide monohydrate; ammonia; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; acetyl chloride; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1197340-84-3
methyl 3-(4-bromophenyl)-4-(4-methoxybenzyloxy)-1H-pyrazole-5-carboxylate

: 1197338-60-5
2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carboximidamide

Guidance literature:: Multi-step reaction with 8 steps

1: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 3 h / 20 °C / Ice bath

2: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 120 °C / Microwave irradiation

3: lithium hydroxide monohydrate / methanol / 0.33 h / 120 °C / Microwave irradiation

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5: acetic acid / 0.92 h / 150 °C / Microwave irradiation

6: trifluoroacetic acid / 0.5 h / 120 °C / Microwave irradiation

7: acetyl chloride / 20 °C / Cooling with ice bath

8: ammonia / methanol / 20 °C

With lithium hydroxide monohydrate; ammonia; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; acetyl chloride; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;