(1S,3aS,5S,7aR)-1-acetoxymethyl-5-(4-cis-tert-butyldimethylsilyloxycyclohexyl)-7a-methylperhydroindene-3a-ol

Base Information

Chemical Name:(1S,3aS,5S,7aR)-1-acetoxymethyl-5-(4-cis-tert-butyldimethylsilyloxycyclohexyl)-7a-methylperhydroindene-3a-ol
CAS No.:392235-30-2
Molecular Formula:C₂₅H₄₆O₄Si
Molecular Weight:438.723
Hs Code.:

Synonyms:(1S,3aS,5S,7aR)-1-acetoxymethyl-5-(4-cis-tert-butyldimethylsilyloxycyclohexyl)-7a-methylperhydroindene-3a-ol

Suppliers and Price of (1S,3aS,5S,7aR)-1-acetoxymethyl-5-(4-cis-tert-butyldimethylsilyloxycyclohexyl)-7a-methylperhydroindene-3a-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,3aS,5S,7aR)-1-acetoxymethyl-5-(4-cis-tert-butyldimethylsilyloxycyclohexyl)-7a-methylperhydroindene-3a-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,3aS,5S,7aR)-1-acetoxymethyl-5-(4-cis-tert-butyldimethylsilyloxycyclohexyl)-7a-methylperhydroindene-3a-ol

There total 11 articles about (1S,3aS,5S,7aR)-1-acetoxymethyl-5-(4-cis-tert-butyldimethylsilyloxycyclohexyl)-7a-methylperhydroindene-3a-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 108-24-7
acetic anhydride

: 392235-28-8
(1S,3aS,5S,7aR)-1-hydroxymethyl-5-(4-cis-tert-butyldimethylsilyloxycyclohexyl)-7a-methylperhydroindene-3a-ol

: 392235-30-2
(1S,3aS,5S,7aR)-1-acetoxymethyl-5-(4-cis-tert-butyldimethylsilyloxycyclohexyl)-7a-methylperhydroindene-3a-ol

Guidance literature:: With pyridine; dmap; at 20 ℃; for 16h;
DOI:10.1021/jm011001k

Reference yield:

: 67963-68-2
t-butyldimethylsilyl-4-bromophenol

: 392235-30-2
(1S,3aS,5S,7aR)-1-acetoxymethyl-5-(4-cis-tert-butyldimethylsilyloxycyclohexyl)-7a-methylperhydroindene-3a-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane / 4 h / 20 °C

1.2: 43 percent / hexane; tetrahydrofuran / 1.5 h / -78 °C

2.1: 53 percent / Ranye-Ni / ethanol / 8 h / Heating

3.1: 50 percent / H₂ / 5percent Rh/Al₂O₃ / methanol / 24 h / 3268.22 Torr

4.1: 100 percent / pyridine; DMAP / 16 h / 20 °C

With pyridine; dmap; n-butyllithium; Ranye-Ni; hydrogen; 5percent Rh/Al₂O₃; In methanol; ethanol; hexane;
DOI:10.1021/jm011001k

Reference yield:

: 33879-04-8,51065-67-9
(+)-(3aS,7aS)-2,3,3a,4,7,7a-hexahydro-3a-hydroxy-7a-methyl-1H-indene-1,5(6H)-dione

: 392235-30-2
(1S,3aS,5S,7aR)-1-acetoxymethyl-5-(4-cis-tert-butyldimethylsilyloxycyclohexyl)-7a-methylperhydroindene-3a-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 83 percent / oxalic acid / acetonitrile / 16 h

2.1: 77 percent / t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 2 h / Heating

3.1: BH₃ / tetrahydrofuran / 1 h / 20 °C

3.2: 20 percent / NaBO₃; aq. NaOH / 16 h / 20 °C

4.1: 68 percent / 1 N pTSA / acetonitrile; H₂O / 16 h

5.1: n-butyllithium / hexane / 4 h / 20 °C

5.2: 43 percent / hexane; tetrahydrofuran / 1.5 h / -78 °C

6.1: 53 percent / Ranye-Ni / ethanol / 8 h / Heating

7.1: 50 percent / H₂ / 5percent Rh/Al₂O₃ / methanol / 24 h / 3268.22 Torr

8.1: 100 percent / pyridine; DMAP / 16 h / 20 °C

With pyridine; dmap; n-butyllithium; Ranye-Ni; borane; potassium tert-butylate; hydrogen; oxalic acid; toluene-4-sulfonic acid; 5percent Rh/Al₂O₃; In tetrahydrofuran; methanol; ethanol; hexane; water; acetonitrile; tert-butyl alcohol; 2.1: Wittig reaction;
DOI:10.1021/jm011001k