Technology Process of C33H37F2N5O7S
There total 5 articles about C33H37F2N5O7S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester;
With
HATU;
In
N,N-dimethyl-formamide;
for 0.05h;
Inert atmosphere;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide;
In
N,N-dimethyl-formamide;
for 3h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / 20 °C
1.2: 0.5 h / 20 °C
2.1: pyridine / 18 h / 21 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C
4.1: HATU / N,N-dimethyl-formamide / 0.05 h / Inert atmosphere
4.3: 3 h
With
pyridine; lithium aluminium tetrahydride; HATU; potassium hydroxide;
In
tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrazine hydrate / butan-1-ol / 23 h / 110 - 115 °C
2.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / 20 °C
2.2: 0.5 h / 20 °C
3.1: pyridine / 18 h / 21 °C / Inert atmosphere
4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C
5.1: HATU / N,N-dimethyl-formamide / 0.05 h / Inert atmosphere
5.3: 3 h
With
pyridine; lithium aluminium tetrahydride; hydrazine hydrate; HATU; potassium hydroxide;
In
tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;
