1-benzoyl-3-(R)-methyl-4-[(7-hydroxycarbonyl-4-azaindol-3-yl)-oxoacetyl]-piperazine

Base Information

Chemical Name:1-benzoyl-3-(R)-methyl-4-[(7-hydroxycarbonyl-4-azaindol-3-yl)-oxoacetyl]-piperazine
CAS No.:446285-48-9
Molecular Formula:C₂₂H₂₀N₄O₅
Molecular Weight:420.425
Hs Code.:

Synonyms:1-benzoyl-3-(R)-methyl-4-[(7-hydroxycarbonyl-4-azaindol-3-yl)-oxoacetyl]-piperazine

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Chemical Property of 1-benzoyl-3-(R)-methyl-4-[(7-hydroxycarbonyl-4-azaindol-3-yl)-oxoacetyl]-piperazine

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Technology Process of 1-benzoyl-3-(R)-methyl-4-[(7-hydroxycarbonyl-4-azaindol-3-yl)-oxoacetyl]-piperazine

There total 4 articles about 1-benzoyl-3-(R)-methyl-4-[(7-hydroxycarbonyl-4-azaindol-3-yl)-oxoacetyl]-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 357262-86-3
C₂₂H₂₂N₄O₃

: 446285-48-9
1-benzoyl-3-(R)-methyl-4-[(7-hydroxycarbonyl-4-azaindol-3-yl)-oxoacetyl]-piperazine

Guidance literature:: With pyridine; selenium(IV) oxide; water; In 1,3-dioxane; Reflux;
DOI:10.1016/j.bmcl.2012.10.120

Reference yield:

: 357263-43-5
5-chloro-7-methyl-1H-pyrrolo[3,2-b]pyridine

: 446285-48-9
1-benzoyl-3-(R)-methyl-4-[(7-hydroxycarbonyl-4-azaindol-3-yl)-oxoacetyl]-piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum (III) chloride / dichloromethane

2: potassium carbonate / methanol; water

3: 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

4: palladium 10% on activated carbon; hydrogen / 2068.65 Torr

5: water; selenium(IV) oxide; pyridine / 1,3-dioxane / Reflux

With pyridine; selenium(IV) oxide; aluminum (III) chloride; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In 1,3-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.120

Reference yield:

: 357262-89-6
1-benzoyl-3-(R)-methyl-4-[(5-chloro-7-methyl-4-azaindol-3-yl)oxoacetyl]piperazine

: 446285-48-9
1-benzoyl-3-(R)-methyl-4-[(7-hydroxycarbonyl-4-azaindol-3-yl)-oxoacetyl]-piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / 2068.65 Torr

2: water; selenium(IV) oxide; pyridine / 1,3-dioxane / Reflux

With pyridine; selenium(IV) oxide; palladium 10% on activated carbon; water; hydrogen; In 1,3-dioxane;
DOI:10.1016/j.bmcl.2012.10.120