N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)--D-2’-deoxyribofuranosyl]guanine

Base Information

Chemical Name:N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)--D-2’-deoxyribofuranosyl]guanine
CAS No.:328394-28-1
Molecular Formula:C₃₅H₅₈BrN₅O₅Si₄
Molecular Weight:821.122
Hs Code.:
Mol file:328394-28-1.mol

N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)--D-2’-deoxyribofuranosyl]guanine

Synonyms:N²-(1,1,4,4-tetramethyldisilylazacyclopentanyl)-O⁶-benzyl-8-bromo-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine

Suppliers and Price of N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)--D-2’-deoxyribofuranosyl]guanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2’-deoxyribofuranosyl]guanine
50mg
$ 1100.00

TRC
N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2’-deoxyribofuranosyl]guanine
5mg
$ 140.00

Total 3 raw suppliers

Chemical Property of N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)--D-2’-deoxyribofuranosyl]guanine

Chemical Property:

Melting Point:93-95°C
Boiling Point:713.3±70.0 °C(Predicted)
PKA:0.42±0.20(Predicted)
Density:1.26±0.1 g/cm3(Predicted)
Solubility.:Chloroform, DMF, DMSO, Ethyl Acetate, Methanol

Purity/Quality:

95% ^*data from raw suppliers

N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2’-deoxyribofuranosyl]guanine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2’-deoxyribofuranosyl]guanine (cas# 328394-28-1) is a compound useful in organic synthesis.

Technology Process of N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)--D-2’-deoxyribofuranosyl]guanine

There total 7 articles about N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)--D-2’-deoxyribofuranosyl]guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 13528-93-3
1,2-bis-(chlorodimethylsilyl)ethane

: 328394-26-9
O⁶-benzyl-8-bromo-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine

: 328394-28-1
N²-(1,1,4,4-tetramethyldisilylazacyclopentanyl)-O⁶-benzyl-8-bromo-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine

Guidance literature:: O⁶-benzyl-8-bromo-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h;

1,2-bis-(chlorodimethylsilyl)ethane; In tetrahydrofuran; at 20 ℃; for 0.333333h;
DOI:10.1021/ja0487022

Reference yield:

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 328394-28-1
N²-(1,1,4,4-tetramethyldisilylazacyclopentanyl)-O⁶-benzyl-8-bromo-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / pyridine / 0 - 20 °C

2.1: 76 percent / PPh₃; DEAD / dioxane / 0 - 20 °C

3.1: LiHMDS / tetrahydrofuran / 0.25 h / -78 °C

3.2: 85 percent / tetrahydrofuran / 0.33 h / 20 °C

With pyridine; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/ja0487022

Reference yield:

: 13389-03-2
8-bromo-2'-deoxyguanosine

: 328394-28-1
N²-(1,1,4,4-tetramethyldisilylazacyclopentanyl)-O⁶-benzyl-8-bromo-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / pyridine / 0 - 20 °C

2.1: 76 percent / PPh₃; DEAD / dioxane / 0 - 20 °C

3.1: LiHMDS / tetrahydrofuran / 0.25 h / -78 °C

3.2: 85 percent / tetrahydrofuran / 0.33 h / 20 °C

With pyridine; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/ja0487022