ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate

Base Information

Chemical Name:ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate
CAS No.:145222-85-1
Molecular Formula:C₃₂H₃₉NO₅Si
Molecular Weight:545.751
Hs Code.:

Synonyms:ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate

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Chemical Property of ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate

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Technology Process of ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate

There total 5 articles about ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145222-83-9
ethyl 6-(hydroxymethyl)-2-methoxy-4-methyl-3-pyridinecarboxylate

: 145222-85-1
ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / DMAP / CH₂Cl₂

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 30 min

With dmap; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/ja00104a009

Reference yield:

: 112463-87-3
ethyl 2-methoxy-4,6-dimethyl-3-pyridinecarboxylate

: 145222-85-1
ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: NBS, AIBN / CCl₄ / 3 h / Heating; Irradiation

2: aq. AgNO₃ / tetrahydrofuran

3: NaBH₄ / ethanol / 1 h / 0 °C

4: 97 percent / DMAP / CH₂Cl₂

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 30 min

With dmap; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); silver nitrate; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane;
DOI:10.1021/ja00104a009

Reference yield:

: 161321-62-6
6-Formyl-2-methoxy-4-methyl-nicotinic acid ethyl ester

: 145222-85-1
ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / ethanol / 1 h / 0 °C

2: 97 percent / DMAP / CH₂Cl₂

3: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 30 min

With dmap; sodium tetrahydroborate; lithium diisopropyl amide; In ethanol; dichloromethane;
DOI:10.1021/ja00104a009