(2R,3R,αR)-3--2-hydroxy-3-phenylpropionic acid

Base Information

Chemical Name:(2R,3R,αR)-3--2-hydroxy-3-phenylpropionic acid
CAS No.:161453-07-2
Molecular Formula:C₂₄H₂₅NO₃
Molecular Weight:375.467
Hs Code.:

(2R,3R,αR)-3-<N-benzyl-N-(α-methylbenzyl)amino>-2-hydroxy-3-phenylpropionic acid

Synonyms:(2R,3R,αR)-3--2-hydroxy-3-phenylpropionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,αR)-3--2-hydroxy-3-phenylpropionic acid

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Technology Process of (2R,3R,αR)-3--2-hydroxy-3-phenylpropionic acid

There total 5 articles about (2R,3R,αR)-3--2-hydroxy-3-phenylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 151671-03-3
tert-butyl (2R,3R,αR)-3--2-hydroxy-3-phenylpropionate

: 161453-07-2
(2R,3R,αR)-3--2-hydroxy-3-phenylpropionic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; Ambient temperature;

Reference yield:

: 14990-09-1
tert-butyl cinnamate

: 161453-07-2
(2R,3R,αR)-3--2-hydroxy-3-phenylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) (+)-(camphorsulfonyl)oxaziridine / 1) THF, -78 deg C, 2 h; 2) THF, -78 deg C (1 h), -78 --> 0 deg C (15 min)

2: 87 percent / trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

With (+)-(2S,8aS)-(camphorylsulfonyl)oxaziridine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 151133-00-5
tert-butyl (3S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

: 161453-07-2
(2R,3R,αR)-3--2-hydroxy-3-phenylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium diisopropylamide, 2.) (+)-(camphorsulfonyl)oxaziridine / 1) THF, 1 h, -78 deg C; 2) THF, -78 deg C (1.5 h), -78 --> 0 deg C (15 min)

2: 87 percent / trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

With (+)-(2S,8aS)-(camphorylsulfonyl)oxaziridine; trifluoroacetic acid; lithium diisopropyl amide; In dichloromethane;