methyl 4'-[[2-[(tert-butoxy-carbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-3-(cyclohexyloxy)-4-biphenylcarboxylate

Base Information

Chemical Name:methyl 4'-[[2-[(tert-butoxy-carbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-3-(cyclohexyloxy)-4-biphenylcarboxylate
CAS No.:881408-65-7
Molecular Formula:C₃₅H₄₃ClN₂O₆
Molecular Weight:623.189
Hs Code.:

Synonyms:methyl 4'-[[2-[(tert-butoxy-carbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-3-(cyclohexyloxy)-4-biphenylcarboxylate

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Chemical Property of methyl 4'-[[2-[(tert-butoxy-carbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-3-(cyclohexyloxy)-4-biphenylcarboxylate

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Technology Process of methyl 4'-[[2-[(tert-butoxy-carbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-3-(cyclohexyloxy)-4-biphenylcarboxylate

There total 1 articles about methyl 4'-[[2-[(tert-butoxy-carbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-3-(cyclohexyloxy)-4-biphenylcarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl [(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]{2-[(4-iodophenyl)amino]ethyl}carbamate

: 855482-72-3
[3-(cyclohexyloxy)-4-(methoxycarbonyl)phenyl]boronic acid

: 881408-65-7
methyl 4'-[[2-[(tert-butoxy-carbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-3-(cyclohexyloxy)-4-biphenylcarboxylate

Guidance literature:: With potassium phosphate; bis(dicyclohexylamine)-palladium(II) acetate; In ethanol; at 60 - 80 ℃; for 9h;

Reference yield:

: 881408-65-7
methyl 4'-[[2-[(tert-butoxy-carbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-3-(cyclohexyloxy)-4-biphenylcarboxylate

: 881408-66-8
4'-[[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-3-(cyclohexyloxy)-4-biphenylcarboxylic acid

Guidance literature:: methyl 4'-[[2-[(tert-butoxy-carbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-3-(cyclohexyloxy)-4-biphenylcarboxylate; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 96h;

With hydrogenchloride; methanol; water; In ethyl acetate; pH=5.70; Product distribution / selectivity;