Technology Process of 4-chloro butyraldehyde
There total 1 articles about 4-chloro butyraldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-chlorobutyraldehyde; sodium cyanide;
With
sodium hydrogensulfite;
In
diethyl ether; water;
at 20 ℃;
for 1h;
ethyl vinyl ether;
With
pyridinium p-toluenesulfonate;
In
dichloromethane;
DOI:10.1016/S0040-4020(98)00448-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 76 percent / sodium hexamethyldisilazane / benzene; tetrahydrofuran / 2 h / 20 °C
2: 87 percent / diethyl ether / 3 h / 20 °C
3: 94 percent / diethyl ether / 2 h / 20 °C
4: 95 percent / CF3COOH / CH2Cl2 / 1 h / 20 °C
With
sodium hexamethyldisilazane; trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; benzene;
1: Cyclization / 2: Grignard reaction / 3: Grignard reaction / 4: Cyclization;
DOI:10.1016/S0040-4020(98)00448-7
