ethyl 3-(benzyl(3-ethoxy-3-oxopropyl)aMino)-2,2-difluoropropanoate

Base Information

• Chemical Name: ethyl 3-(benzyl(3-ethoxy-3-oxopropyl)aMino)-2,2-difluoropropanoate
• CAS No.: 851314-55-1
• Molecular Formula: C₁₇H₂₃F₂NO₄
• Molecular Weight: 343.371
• Hs Code.: 2918199890
• Mol file: 851314-55-1.mol

Synonyms:ethyl N-[3-(ethyloxy)-2,2-difluoro-3-oxopropyl]-N-(phenylmethyl)-beta-alaninate

Chemical Property of ethyl 3-(benzyl(3-ethoxy-3-oxopropyl)aMino)-2,2-difluoropropanoate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 3-[benzyl(3-ethoxy-3-oxopropyl)amino]-2,2-difluoropropanoate ^*data from reagent suppliers

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SDS file from LookChem

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Technology Process of ethyl 3-(benzyl(3-ethoxy-3-oxopropyl)aMino)-2,2-difluoropropanoate

There total 2 articles about ethyl 3-(benzyl(3-ethoxy-3-oxopropyl)aMino)-2,2-difluoropropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl N-(1H-1,2,3-benzotriazol-1-ylmethyl)-N-(phenylmethyl)-beta-alaninate (851314-54-0) + Ethyl bromodifluoroacetate (667-27-6) → ethyl N-[3-(ethyloxy)-2,2-difluoro-3-oxopropyl]-N-(phenylmethyl)-beta-alaninate (851314-55-1)

Guidance literature:

Ethyl bromodifluoroacetate; With chloro-trimethyl-silane; zinc; In tetrahydrofuran; for 0.166667h;

ethyl N-(1H-1,2,3-benzotriazol-1-ylmethyl)-N-(phenylmethyl)-beta-alaninate; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

ethyl-3-benzylamino propionate (23583-21-3) → ethyl N-[3-(ethyloxy)-2,2-difluoro-3-oxopropyl]-N-(phenylmethyl)-beta-alaninate (851314-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol; water / 16 h / 20 °C

2.1: chloro-trimethyl-silane; zinc / tetrahydrofuran / 0.17 h / 20 °C

2.2: 18 h / 20 °C

With chloro-trimethyl-silane; zinc; In tetrahydrofuran; methanol; water;

Reference yield: 81.0%

ethyl N-[3-(ethyloxy)-2,2-difluoro-3-oxopropyl]-N-(phenylmethyl)-beta-alaninate (851314-55-1) → ethyl 1-benzyl-5,5-difluoro-4-oxopiperidine-3-carboxylate (1067915-34-7)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃;

upstream raw materials:

ethyl N-(1H-1,2,3-benzotriazol-1-ylmethyl)-N-(phenylmethyl)-beta-alaninate

Ethyl bromodifluoroacetate

ethyl-3-benzylamino propionate

Downstream raw materials:

ethyl 1-benzyl-5,5-difluoro-4-oxopiperidine-3-carboxylate

3,3-difluoro-1-(phenylmethyl)-4,4-piperidinediol

tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate

(±)-tert-butyl 4-(benzylamino)-3,3-difluoropiperidine-1-carboxylate

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