(25R)-3β,16β-dihydroxycholesterol 26-tosylate

Base Information

• Chemical Name: (25R)-3β,16β-dihydroxycholesterol 26-tosylate
• CAS No.: 71472-98-5
• Molecular Formula: C₃₄H₅₂O₅S
• Molecular Weight: 572.85
• Mol file: 71472-98-5.mol

Synonyms:(25R)-3β,16β-dihydroxycholesterol 26-tosylate

Chemical Property of (25R)-3β,16β-dihydroxycholesterol 26-tosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (25R)-3β,16β-dihydroxycholesterol 26-tosylate

There total 2 articles about (25R)-3β,16β-dihydroxycholesterol 26-tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(25R)-cholest-5-ene-3β,16β,26-triol (31327-56-7) + p-toluenesulfonyl chloride (98-59-9) → (25R)-16β-hydroxycholesterol 3β,26-ditosylate (153210-05-0) + (25R)-3β,16β-dihydroxycholesterol 26-tosylate (71472-98-5)

Guidance literature:

With pyridine; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2007.05.003

Reference yield:

diosgenin (512-04-9) → (25R)-3β,16β-dihydroxycholesterol 26-tosylate (71472-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / Zn-Hg; aq. HCl / ethanol / 0.5 h / Heating

2: 30 percent / pyridine / 24 h / 20 °C

With hydrogenchloride; mercury; zinc; In pyridine; ethanol; 1: Clemmensen reduction;

DOI:10.1016/j.steroids.2006.03.002

upstream raw materials:

(25R)-cholest-5-ene-3β,16β,26-triol

p-toluenesulfonyl chloride

diosgenin