N-((2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)thiazol-4-yl)methyl)-4-(methylsulfonyl)aniline

Base Information

Chemical Name:N-((2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)thiazol-4-yl)methyl)-4-(methylsulfonyl)aniline
CAS No.:1361391-52-7
Molecular Formula:C₂₃H₂₈N₄O₃S₂
Molecular Weight:472.632
Hs Code.:

Synonyms:N-((2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)thiazol-4-yl)methyl)-4-(methylsulfonyl)aniline

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Chemical Property of N-((2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)thiazol-4-yl)methyl)-4-(methylsulfonyl)aniline

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Technology Process of N-((2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)thiazol-4-yl)methyl)-4-(methylsulfonyl)aniline

There total 4 articles about N-((2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)thiazol-4-yl)methyl)-4-(methylsulfonyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.4%

: 1361391-35-6
4-(chloromethyl)-2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl) thiazole

: 177662-76-9
(4-methylsulfonyl)aniline hydrochloride

: 1361391-52-7
N-((2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)thiazol-4-yl)methyl)-4-(methylsulfonyl)aniline

Guidance literature:: With N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; at 100 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 1361391-16-3
4-(5-ethylpyrimidin-2-yloxy)cyclohexanone

: 1361391-52-7
N-((2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)thiazol-4-yl)methyl)-4-(methylsulfonyl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / 1,2-dimethoxyethane; ethanol / 1.5 h / 0 - 43 °C

2: tetraphosphorus decasulfide / ethanol / 3 h / Reflux

3: magnesium sulfate / acetone / 15 h / Reflux

4: N-ethyl-N,N-diisopropylamine; sodium iodide / acetonitrile / 0.17 h / 100 °C / Microwave irradiation

With tetraphosphorus decasulfide; potassium tert-butylate; magnesium sulfate; N-ethyl-N,N-diisopropylamine; sodium iodide; In 1,2-dimethoxyethane; ethanol; acetone; acetonitrile;

Reference yield:

: 1361391-29-8
4-(5-ethylpyrimidin-2-yloxy)cyclohexanecarbonitrile

: 1361391-52-7
N-((2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)thiazol-4-yl)methyl)-4-(methylsulfonyl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: tetraphosphorus decasulfide / ethanol / 3 h / Reflux

2: magnesium sulfate / acetone / 15 h / Reflux

3: N-ethyl-N,N-diisopropylamine; sodium iodide / acetonitrile / 0.17 h / 100 °C / Microwave irradiation

With tetraphosphorus decasulfide; magnesium sulfate; N-ethyl-N,N-diisopropylamine; sodium iodide; In ethanol; acetone; acetonitrile;