1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid

Base Information

Chemical Name:1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid
CAS No.:607354-69-8
Molecular Formula:C13H14 F3 N O2
Molecular Weight:273.255
Hs Code.:2933399090
DSSTox Substance ID:DTXSID60452723
Nikkaji Number:J1.920.091D
Wikidata:Q82273522
Mol file:607354-69-8.mol

Synonyms:1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid;607354-69-8;1-[4-(trifluoromethyl)phenyl]piperidine-4-carboxylic Acid;1-(4-(Trifluoromethyl)phenyl)piperidine-4-carboxylic acid;MFCD05864757;1-(4-Trifluoromethylphenyl)piperidine-4-carboxylicacid;SCHEMBL2071701;DTXSID60452723;BCP23278;AKOS006225350;CS-W021238;DS-0107;AM20040834;FT-0655302;A832861;J-503382;1-(4-trifluoromethyl-phenyl)-piperidine-4-carboxylic acid;4-Piperidinecarboxylicacid,1-[4-(trifluoromethyl)phenyl]-

Suppliers and Price of 1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(4-Trifluoromethylphenyl)piperidine-4-carboxylicAcid
10mg
$ 45.00

SynChem
1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid 95+%
10 g
$ 700.00

SynChem
1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid 95+%
5 g
$ 400.00

SynChem
1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid 95+%
1 g
$ 100.00

Matrix Scientific
1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid 95+%
10g
$ 1250.00

Matrix Scientific
1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid 95+%
5g
$ 798.00

Matrix Scientific
1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid 95+%
1g
$ 231.00

Crysdot
1-(4-Trifluoromethylphenyl)piperidine-4-carboxylicacid 97%
10g
$ 354.00

Chemenu
1-(4-Trifluoromethylphenyl)piperidine-4-carboxylicacid 97%
5g
$ 191.00

Chemenu
1-(4-Trifluoromethylphenyl)piperidine-4-carboxylicacid 97%
10g
$ 334.00

Total 32 raw suppliers

Chemical Property of 1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:395.739°C at 760 mmHg
Flash Point:193.136°C
PSA：40.54000
Density:1.317g/cm³
LogP:3.07140
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:273.09766318
Heavy Atom Count:19
Complexity:316

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Trifluoromethylphenyl)piperidine-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1C(=O)O)C2=CC=C(C=C2)C(F)(F)F

Technology Process of 1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid

There total 5 articles about 1-(4-Trifluoromethylphenyl)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: ethyl 1-(4-(trifluoromethyl)phenyl)piperidine-4-carboxylate

: 607354-69-8
1-(4-(trifluoromethyl)phenyl)piperidine-4-carboxyli c acid

Guidance literature:: ethyl 1-(4-(trifluoromethyl)phenyl)piperidine-4-carboxylate; With methanol; sodium hydroxide; water; for 0.5h; Heating / reflux;

With hydrogenchloride; water;

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 607354-69-8
1-(4-(trifluoromethyl)phenyl)piperidine-4-carboxyli c acid

Guidance literature:: Multi-step reaction with 2 steps

1: BINAP; NaO-t-Bu; Pd₂(dba)3 / toluene / 2 h / microwave irradiation

2: aq. KOH / tetrahydrofuran; methanol

With potassium hydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; methanol; toluene;
DOI:10.1081/SCC-120021042

Reference yield:

: 402-43-7
p-trifluoromethylphenyl bromide

: 607354-69-8
1-(4-(trifluoromethyl)phenyl)piperidine-4-carboxyli c acid

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 90 °C

2: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; lithium hydroxide; sodium t-butanolate; In tetrahydrofuran; toluene;