3-[2-(2-methoxyphenylethynyl)naphthalen-1-yl]propynoic acid N-(4-methoxybenzyl)-N-(naphthalen-2-yl)amide

Base Information

Chemical Name:3-[2-(2-methoxyphenylethynyl)naphthalen-1-yl]propynoic acid N-(4-methoxybenzyl)-N-(naphthalen-2-yl)amide
CAS No.:1589489-80-4
Molecular Formula:C₄₀H₂₉NO₃
Molecular Weight:571.675
Hs Code.:

Synonyms:3-[2-(2-methoxyphenylethynyl)naphthalen-1-yl]propynoic acid N-(4-methoxybenzyl)-N-(naphthalen-2-yl)amide

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Chemical Property of 3-[2-(2-methoxyphenylethynyl)naphthalen-1-yl]propynoic acid N-(4-methoxybenzyl)-N-(naphthalen-2-yl)amide

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Technology Process of 3-[2-(2-methoxyphenylethynyl)naphthalen-1-yl]propynoic acid N-(4-methoxybenzyl)-N-(naphthalen-2-yl)amide

There total 5 articles about 3-[2-(2-methoxyphenylethynyl)naphthalen-1-yl]propynoic acid N-(4-methoxybenzyl)-N-(naphthalen-2-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 767-91-9
1-ethynyl-2-methoxybenzene

: 1589489-99-5
C₃₂H₂₂F₃NO₅S

: 1589489-80-4
3-[2-(2-methoxyphenylethynyl)naphthalen-1-yl]propynoic acid N-(4-methoxybenzyl)-N-(naphthalen-2-yl)amide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 60 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ja500841f

Reference yield:

: 3-[2-(methoxymethoxy)-1-naphthalenyl]-2-propynoic acid

: 1589489-80-4
3-[2-(2-methoxyphenylethynyl)naphthalen-1-yl]propynoic acid N-(4-methoxybenzyl)-N-(naphthalen-2-yl)amide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 4 h / 0 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

3: hydrogenchloride / water / 16 h / 20 °C

4: triethylamine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

5: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere

With hydrogenchloride; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; triethylamine; In tetrahydrofuran; dichloromethane; water; 5: |Sonogashira Cross-Coupling;
DOI:10.1021/ja500841f

Reference yield:

: 1589489-82-6
C₃₃H₂₇NO₄

: 1589489-80-4
3-[2-(2-methoxyphenylethynyl)naphthalen-1-yl]propynoic acid N-(4-methoxybenzyl)-N-(naphthalen-2-yl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 16 h / 20 °C

2: triethylamine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; dichloromethane; water; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/ja500841f