(1R,2S)-(+)-trans-1-(Hydroxymethyl)-2-phenyl-1,2-dihydronaphthalene

Base Information

• Chemical Name: (1R,2S)-(+)-trans-1-(Hydroxymethyl)-2-phenyl-1,2-dihydronaphthalene
• CAS No.: 99797-48-5
• Molecular Formula: C₁₇H₁₆O
• Molecular Weight: 236.313
• Mol file: 99797-48-5.mol

Synonyms:(1R,2S)-(+)-trans-1-(Hydroxymethyl)-2-phenyl-1,2-dihydronaphthalene

Chemical Property of (1R,2S)-(+)-trans-1-(Hydroxymethyl)-2-phenyl-1,2-dihydronaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-(+)-trans-1-(Hydroxymethyl)-2-phenyl-1,2-dihydronaphthalene

There total 11 articles about (1R,2S)-(+)-trans-1-(Hydroxymethyl)-2-phenyl-1,2-dihydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-4-methoxy-N-(naphthalene-1-ylmethylene)phenylamine (3525-60-8) + phenyllithium (591-51-5) → trans-2-phenyl-1,2-dihydro-1-naphthalenylmethanol (99797-48-5,99797-53-2,126059-97-0,126059-93-6) + 4-methoxy-N-[naphthalen-1-yl(phenyl)methyl]aniline

Guidance literature:

(E)-4-methoxy-N-(naphthalene-1-ylmethylene)phenylamine; phenyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; hexane; at 20 ℃; for 1h;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.166667h; Further stages.;

DOI:10.1021/jo015766b

Reference yield: 39.0%

phenyllithium (591-51-5) + N-(naphthalene-1-ylmethylene)butylamine (92645-94-8) → trans-2-phenyl-1,2-dihydro-1-naphthalenylmethanol (99797-48-5,99797-53-2,126059-97-0,126059-93-6) + (2-phenyl-naphthalen-1-yl)-methanol

Guidance literature:

phenyllithium; N-(naphthalene-1-ylmethylene)butylamine; In tetrahydrofuran; hexane; at -45 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; hexane; at 20 ℃; for 12h;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.166667h; Further stages.;

DOI:10.1021/jo015766b

Reference yield: 33.0%

phenyllithium (591-51-5) + N-(naphthalen-1-ylmethylene)cyclohexylamine (4323-24-4) → trans-2-phenyl-1,2-dihydro-1-naphthalenylmethanol (99797-48-5,99797-53-2,126059-97-0,126059-93-6) + (2-phenyl-naphthalen-1-yl)-methanol

Guidance literature:

phenyllithium; N-(naphthalen-1-ylmethylene)cyclohexylamine; In tetrahydrofuran; hexane; at -45 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; hexane; at 20 ℃; for 12h;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.166667h; Further stages.;

DOI:10.1021/jo015766b

upstream raw materials:

2,6-di-tert-butyl-4-(methoxyphenyl)-1-naphthalenecarboxylate

phenyllithium

(E)-4-methoxy-N-(naphthalene-1-ylmethylene)phenylamine

N-(naphthalen-1-ylmethylene)cyclohexylamine