8-(benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine

Base Information

• Chemical Name: 8-(benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine
• CAS No.: 1032570-69-6
• Molecular Formula: C₁₈H₁₈N₄O₂
• Molecular Weight: 322.367
• Mol file: 1032570-69-6.mol

Synonyms:8-(benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine

Chemical Property of 8-(benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine

There total 11 articles about 8-(benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

cyanogen bromide + 3-(benzyloxy)-6-(4,5-dihydro-1H-imidazol-2-yl)-2-methoxyaniline (887202-50-8) → 8-(benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine (1032570-69-6)

Guidance literature:

With triethylamine; In dichloromethane; at 5 - 22 ℃; for 1h; Solvent; Temperature; Large scale;

Reference yield:

3-(benzyloxy)-6-(4,5-dihydro-1H-imidazol-2-yl)-2-methoxyaniline (887202-50-8) → 8-(benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine (1032570-69-6)

Guidance literature:

With bromocyane; triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

4-(benzyloxy)-3-methoxy-2-nitrobenzaldehyde (2450-27-3) → 8-(benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine (1032570-69-6)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium hydroxide; iodine / tetrahydrofuran / 16 h

2: acetic acid; iron / water / 72 h / 5 °C

3: sulfur / 16 h / 100 °C

4: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With ammonium hydroxide; iodine; iron; acetic acid; triethylamine; sulfur; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

vanillin acetate

4-(benzyloxy)-3-methoxy-2-nitrobenzaldehyde

4-(benzyloxy)-3-methoxy-2-nitrobenzonitrile

2-amino-4-(benzyloxy)-3-methoxybenzonitrile

Downstream raw materials:

N-[8-(benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]nicotinamide

N-(8-{[(2R)-2-hydroxy-3-(morpholin-4-yl)propyl]oxy}-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-2-methylpyridine-3-carboxamide