2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-[N-(3-carboxyphenyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide

Base Information

Chemical Name:2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-[N-(3-carboxyphenyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide
CAS No.:201677-81-8
Molecular Formula:C₃₉H₃₃F₂N₅O₈
Molecular Weight:737.717
Hs Code.:

2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-[N-(3-carboxyphenyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide

Synonyms:2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-[N-(3-carboxyphenyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide

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Chemical Property of 2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-[N-(3-carboxyphenyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide

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Technology Process of 2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-[N-(3-carboxyphenyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide

There total 6 articles about 2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-[N-(3-carboxyphenyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 201677-80-7
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-[N-(3-tert-butyloxycarbonylphenyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide

: 201677-81-8
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-[N-(3-carboxyphenyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5.5h;
DOI:10.1021/jm000497n

Reference yield:

: 59830-60-3,63219-70-5,68474-26-0
N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde

: 201677-81-8
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-[N-(3-carboxyphenyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / aq. K₂CO₃ / tetrahydrofuran; methanol / 20 °C

2: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

3: H₂; 1 N aq. HCl / 10percent Pd/C / methanol / 15 h / 20 °C

4: N-ethylmorpholine; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; 3-hydroxybenzotriazole hydrate / dimethylformamide / 16 h / 20 °C

5: Dess-Martin periodinate / dimethylformamide / 14 h / 20 °C

6: 86 percent / trifluoroacetic acid / CH₂Cl₂ / 5.5 h / 20 °C

With N-ethylmorpholine;; hydrogenchloride; hydrogen; potassium carbonate; Dess-Martin periodane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 5: Dess-Martin oxidation;
DOI:10.1021/jm000497n

Reference yield:

: 4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxybutanoic acid

: 201677-81-8
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-[N-(3-carboxyphenyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

2: H₂; 1 N aq. HCl / 10percent Pd/C / methanol / 15 h / 20 °C

3: N-ethylmorpholine; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; 3-hydroxybenzotriazole hydrate / dimethylformamide / 16 h / 20 °C

4: Dess-Martin periodinate / dimethylformamide / 14 h / 20 °C

5: 86 percent / trifluoroacetic acid / CH₂Cl₂ / 5.5 h / 20 °C

With N-ethylmorpholine;; hydrogenchloride; hydrogen; Dess-Martin periodane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; 10percent Pd/C; In methanol; dichloromethane; N,N-dimethyl-formamide; 4: Dess-Martin oxidation;
DOI:10.1021/jm000497n