coumestrol

Base Information

Chemical Name:coumestrol
CAS No.:796089-78-6
Molecular Formula:C₁₅H₁₀O₆
Molecular Weight:286.241
Hs Code.:

Synonyms:coumestrol

Suppliers and Price of coumestrol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of coumestrol

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of coumestrol

There total 25 articles about coumestrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 2-(2,4-dimethoxyphenyl)-6-methoxybenzofuran-3-carboxylate

: 796089-78-6
coumestrol

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 6626-15-9
4-Bromoresorcinol

: 796089-78-6
coumestrol

Guidance literature:: Multi-step reaction with 9 steps

1: K₂CO₃ / acetone / 21 h / Heating

2: 15.0 g / acetone / 3 h / Heating

3: 94 percent / KI; CuI / hexamethylphosphoric acid triamide / 3 h / 150 °C

4: 98 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / dimethylformamide / 1 h / 20 °C

5: 99 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C

6: 96 percent / CuI; i-Pr₂NH / PdCl₂(PPh₃)2 / dimethylformamide / 1.5 h / 60 °C

7: 71 percent / K₂CO₃; CuCl₂*2H₂O; NaOAc / PdCl₂(PPh₃)2 / 48 h / 20 °C

8: 72 percent / BBr₃ / CH₂Cl₂ / 30.5 h / -78 - -40 °C

9: KOH / tetrahydrofuran / 2 h / Heating

With potassium hydroxide; copper(l) iodide; tetrabutyl ammonium fluoride; sodium acetate; boron tribromide; potassium carbonate; triethylamine; diisopropylamine; potassium iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide; acetone; 4: Sonogashira reaction;
DOI:10.1039/b006623k

Reference yield:

: 494773-45-4
4-bromo-3-hydroxy-phenyl 4-methyl-benzenesulfonate

: 796089-78-6
coumestrol

Guidance literature:: Multi-step reaction with 8 steps

1: 15.0 g / acetone / 3 h / Heating

2: 94 percent / KI; CuI / hexamethylphosphoric acid triamide / 3 h / 150 °C

3: 98 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / dimethylformamide / 1 h / 20 °C

4: 99 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C

5: 96 percent / CuI; i-Pr₂NH / PdCl₂(PPh₃)2 / dimethylformamide / 1.5 h / 60 °C

6: 71 percent / K₂CO₃; CuCl₂*2H₂O; NaOAc / PdCl₂(PPh₃)2 / 48 h / 20 °C

7: 72 percent / BBr₃ / CH₂Cl₂ / 30.5 h / -78 - -40 °C

8: KOH / tetrahydrofuran / 2 h / Heating

With potassium hydroxide; copper(l) iodide; tetrabutyl ammonium fluoride; sodium acetate; boron tribromide; potassium carbonate; triethylamine; diisopropylamine; potassium iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide; acetone; 3: Sonogashira reaction;
DOI:10.1039/b006623k