6-(tetrahydropyran-2-yloxy)hexyl 13-(tert-butyldiphenylsilyloxy)tridec-8-ynyl ether

Base Information

Chemical Name:6-(tetrahydropyran-2-yloxy)hexyl 13-(tert-butyldiphenylsilyloxy)tridec-8-ynyl ether
CAS No.:622842-30-2
Molecular Formula:C₄₀H₆₂O₄Si
Molecular Weight:635.015
Hs Code.:

Synonyms:6-(tetrahydropyran-2-yloxy)hexyl 13-(tert-butyldiphenylsilyloxy)tridec-8-ynyl ether

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Chemical Property of 6-(tetrahydropyran-2-yloxy)hexyl 13-(tert-butyldiphenylsilyloxy)tridec-8-ynyl ether

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Technology Process of 6-(tetrahydropyran-2-yloxy)hexyl 13-(tert-butyldiphenylsilyloxy)tridec-8-ynyl ether

There total 4 articles about 6-(tetrahydropyran-2-yloxy)hexyl 13-(tert-butyldiphenylsilyloxy)tridec-8-ynyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 65785-44-6
6-iodohexanol, tetrahydropyranyl ether

: 240427-79-6
1-(tert-butyldiphenylsilyloxy)-tridec-5-yn-13-ol

: 622842-30-2
6-(tetrahydropyran-2-yloxy)hexyl 13-(tert-butyldiphenylsilyloxy)tridec-8-ynyl ether

Guidance literature:: With 15-crown-5; tetrabutyl-ammonium chloride; sodium hydride; In tetrahydrofuran; for 4h; Heating;

Reference yield:

: 928-90-5
5-hexyl-1-ol

: 622842-30-2
6-(tetrahydropyran-2-yloxy)hexyl 13-(tert-butyldiphenylsilyloxy)tridec-8-ynyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / AgNO₃; pyridine / tetrahydrofuran / 12 h / 20 °C

2: n-BuLi; HMPA / tetrahydrofuran; hexane / 14 h / -40 - 20 °C

3: 92 percent / pyridinium p-toluenesulfonate; MeOH / 20 °C

4: 31 percent / NaH; 15-crown-5; n-Bu₄NCl / tetrahydrofuran / 4 h / Heating

With pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 15-crown-5; tetrabutyl-ammonium chloride; pyridinium p-toluenesulfonate; sodium hydride; silver nitrate; In tetrahydrofuran; hexane;

Reference yield:

: 128217-23-2
1-(tert-butyldiphenylsilyloxy)-5-hexyne

: 622842-30-2
6-(tetrahydropyran-2-yloxy)hexyl 13-(tert-butyldiphenylsilyloxy)tridec-8-ynyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi; HMPA / tetrahydrofuran; hexane / 14 h / -40 - 20 °C

2: 92 percent / pyridinium p-toluenesulfonate; MeOH / 20 °C

3: 31 percent / NaH; 15-crown-5; n-Bu₄NCl / tetrahydrofuran / 4 h / Heating

With methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 15-crown-5; tetrabutyl-ammonium chloride; pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; hexane;