Technology Process of 6-(tetrahydropyran-2-yloxy)hexyl 13-(tert-butyldiphenylsilyloxy)tridec-8-ynyl ether
There total 4 articles about 6-(tetrahydropyran-2-yloxy)hexyl 13-(tert-butyldiphenylsilyloxy)tridec-8-ynyl ether which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
15-crown-5; tetrabutyl-ammonium chloride; sodium hydride;
In
tetrahydrofuran;
for 4h;
Heating;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86 percent / AgNO3; pyridine / tetrahydrofuran / 12 h / 20 °C
2: n-BuLi; HMPA / tetrahydrofuran; hexane / 14 h / -40 - 20 °C
3: 92 percent / pyridinium p-toluenesulfonate; MeOH / 20 °C
4: 31 percent / NaH; 15-crown-5; n-Bu4NCl / tetrahydrofuran / 4 h / Heating
With
pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 15-crown-5; tetrabutyl-ammonium chloride; pyridinium p-toluenesulfonate; sodium hydride; silver nitrate;
In
tetrahydrofuran; hexane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: n-BuLi; HMPA / tetrahydrofuran; hexane / 14 h / -40 - 20 °C
2: 92 percent / pyridinium p-toluenesulfonate; MeOH / 20 °C
3: 31 percent / NaH; 15-crown-5; n-Bu4NCl / tetrahydrofuran / 4 h / Heating
With
methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 15-crown-5; tetrabutyl-ammonium chloride; pyridinium p-toluenesulfonate; sodium hydride;
In
tetrahydrofuran; hexane;
