(E)-methyl 3-methoxy-2-(2-(((6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)acrylate

Base Information

Chemical Name:(E)-methyl 3-methoxy-2-(2-(((6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)acrylate
CAS No.:1257598-53-0
Molecular Formula:C₂₃H₁₇F₆N₃O₄
Molecular Weight:513.396
Hs Code.:

Synonyms:(E)-methyl 3-methoxy-2-(2-(((6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)acrylate

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Chemical Property of (E)-methyl 3-methoxy-2-(2-(((6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)acrylate

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Technology Process of (E)-methyl 3-methoxy-2-(2-(((6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)acrylate

There total 3 articles about (E)-methyl 3-methoxy-2-(2-(((6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 117428-51-0
methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate

: 1257599-43-1
C₁₁H₅F₆N₃O

: 1257598-53-0
(E)-methyl 3-methoxy-2-(2-(((6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)acrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;
DOI:10.1016/j.bmcl.2013.04.045

Reference yield: 68.9%

: 117428-51-0
methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate

: 1257599-43-1
C₁₁H₅F₆N₃O

: 1257598-53-0
(E)-methyl 3-methoxy-2-(2-(((6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)acrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.cclet.2013.10.006

Reference yield:

: 3862-73-5
2,3,4-trifluoroaniline

: 1257598-53-0
(E)-methyl 3-methoxy-2-(2-(((6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; hydrogenchloride / water

2: toluene / Reflux; Dean-Stark

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

With hydrogenchloride; sodium carbonate; potassium carbonate; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2013.04.045