{[2-({2-[Benzyl-((S)-1-{2-[((S)-sec-butyl)-(2,2-dimethyl-propionyl)-amino]-acetyl}-pyrrolidine-2-carbonyl)-amino]-acetyl}-carbamoylmethyl-amino)-acetyl]-isobutyl-amino}-acetic acid tert-butyl ester

Base Information

Chemical Name:{[2-({2-[Benzyl-((S)-1-{2-[((S)-sec-butyl)-(2,2-dimethyl-propionyl)-amino]-acetyl}-pyrrolidine-2-carbonyl)-amino]-acetyl}-carbamoylmethyl-amino)-acetyl]-isobutyl-amino}-acetic acid tert-butyl ester
CAS No.:198225-19-3
Molecular Formula:C₃₉H₆₂N₆O₈
Molecular Weight:742.957
Hs Code.:

{[2-({2-[Benzyl-((S)-1-{2-[((S)-sec-butyl)-(2,2-dimethyl-propionyl)-amino]-acetyl}-pyrrolidine-2-carbonyl)-amino]-acetyl}-carbamoylmethyl-amino)-acetyl]-isobutyl-amino}-acetic acid tert-butyl ester

Synonyms:{[2-({2-[Benzyl-((S)-1-{2-[((S)-sec-butyl)-(2,2-dimethyl-propionyl)-amino]-acetyl}-pyrrolidine-2-carbonyl)-amino]-acetyl}-carbamoylmethyl-amino)-acetyl]-isobutyl-amino}-acetic acid tert-butyl ester

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Chemical Property of {[2-({2-[Benzyl-((S)-1-{2-[((S)-sec-butyl)-(2,2-dimethyl-propionyl)-amino]-acetyl}-pyrrolidine-2-carbonyl)-amino]-acetyl}-carbamoylmethyl-amino)-acetyl]-isobutyl-amino}-acetic acid tert-butyl ester

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Technology Process of {[2-({2-[Benzyl-((S)-1-{2-[((S)-sec-butyl)-(2,2-dimethyl-propionyl)-amino]-acetyl}-pyrrolidine-2-carbonyl)-amino]-acetyl}-carbamoylmethyl-amino)-acetyl]-isobutyl-amino}-acetic acid tert-butyl ester

There total 7 articles about {[2-({2-[Benzyl-((S)-1-{2-[((S)-sec-butyl)-(2,2-dimethyl-propionyl)-amino]-acetyl}-pyrrolidine-2-carbonyl)-amino]-acetyl}-carbamoylmethyl-amino)-acetyl]-isobutyl-amino}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 198225-18-2
{[2-(Carbamoylmethyl-amino)-acetyl]-isobutyl-amino}-acetic acid tert-butyl ester

: 198225-17-1
[Benzyl-((S)-1-{2-[((S)-sec-butyl)-(2,2-dimethyl-propionyl)-amino]-acetyl}-pyrrolidine-2-carbonyl)-amino]-acetic acid

: 198225-19-3
{[2-({2-[Benzyl-((S)-1-{2-[((S)-sec-butyl)-(2,2-dimethyl-propionyl)-amino]-acetyl}-pyrrolidine-2-carbonyl)-amino]-acetyl}-carbamoylmethyl-amino)-acetyl]-isobutyl-amino}-acetic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1016/S0040-4039(97)10028-4

Reference yield:

: 106133-00-0
N-bromoacetyl-(S)-proline benzyl ester

: 198225-19-3
{[2-({2-[Benzyl-((S)-1-{2-[((S)-sec-butyl)-(2,2-dimethyl-propionyl)-amino]-acetyl}-pyrrolidine-2-carbonyl)-amino]-acetyl}-carbamoylmethyl-amino)-acetyl]-isobutyl-amino}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / diisopropylethylamine / acetonitrile / 0.5 h / 0 °C

2: 93 percent / diisopropylethylamine / CH₂Cl₂ / 1 h / 0 °C

3: H₂ / 10percent Pd-C / methanol / 1 h / Ambient temperature

4: 87 percent / DCC, HOBT / CH₂Cl₂ / 1 h / Ambient temperature

5: 0.1M KOH / ethanol / 12 h / Ambient temperature

6: 84 percent / DCC, HOBT / CH₂Cl₂ / 3 h / Ambient temperature

With potassium hydroxide; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(97)10028-4

Reference yield:

: 198225-13-7
(S)-1-[2-((S)-sec-Butylamino)-acetyl]-pyrrolidine-2-carboxylic acid benzyl ester

: 198225-19-3
{[2-({2-[Benzyl-((S)-1-{2-[((S)-sec-butyl)-(2,2-dimethyl-propionyl)-amino]-acetyl}-pyrrolidine-2-carbonyl)-amino]-acetyl}-carbamoylmethyl-amino)-acetyl]-isobutyl-amino}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / diisopropylethylamine / CH₂Cl₂ / 1 h / 0 °C

2: H₂ / 10percent Pd-C / methanol / 1 h / Ambient temperature

3: 87 percent / DCC, HOBT / CH₂Cl₂ / 1 h / Ambient temperature

4: 0.1M KOH / ethanol / 12 h / Ambient temperature

5: 84 percent / DCC, HOBT / CH₂Cl₂ / 3 h / Ambient temperature

With potassium hydroxide; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane;
DOI:10.1016/S0040-4039(97)10028-4