5-FLUORO-4-HYDROXYQUINAZOLINE

Base Information

• Chemical Name: 5-FLUORO-4-HYDROXYQUINAZOLINE
• CAS No.: 436-72-6
• Molecular Formula: C8H5FN2O
• Molecular Weight: 164.14
• Hs Code.: 2933990090
• Mol file: 436-72-6.mol

Synonyms:4(1H)-Quinazolinone,5-fluoro- (9CI);5-Fluoro-3,4-dihydro-3H-quinazolin-4-one;5-Fluoro-3,4-dihydroquinazolin-4-one;5-Fluoro-3H-quinazolin-4-one;5-Fluoroquinazolin-4(3H)-one;

Chemical Property of 5-FLUORO-4-HYDROXYQUINAZOLINE

Chemical Property:

• Melting Point: 238 °C
• Boiling Point: 317.5 °C at 760 mmHg
• PKA: -0.02±0.20(Predicted)
• Flash Point: 145.8 °C
• PSA: 46.01000
• Density: 1.44 g/cm³
• LogP: 1.47450
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-Fluoro-4-quinazolone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22-41-37/38
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-4-HYDROXYQUINAZOLINE

There total 7 articles about 5-FLUORO-4-HYDROXYQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.8%

orthoformic acid triethyl ester (122-51-0) + 2-amino-6-fluorobenzamide (115643-59-9) → 5-fluoroquinazolin-4(3H)-one (436-72-6)

Guidance literature:

at 140 ℃; for 72h;

Reference yield: 85.0%

2-amino-6-fluorobenzoic acid (434-76-4) + formamide (77287-34-4,77287-35-5,60100-09-6) → 5-fluoroquinazolin-4(3H)-one (436-72-6)

Guidance literature:

at 140 ℃;

DOI:10.1016/j.ejmech.2012.02.001

Reference yield: 82.0%

oxalic acid (144-62-7,97993-78-7) + 2-amino-6-fluorobenzamide (115643-59-9) → 5-fluoroquinazolin-4(3H)-one (436-72-6)

Guidance literature:

In 1,4-dioxane; at 120 ℃; for 20h; Green chemistry;

DOI:10.1039/c7ob03064a

upstream raw materials:

orthoformic acid triethyl ester

2-amino-6-fluorobenzamide

2-amino-6-fluorobenzoic acid

formamide

Downstream raw materials:

4-chloro-5-fluoro-quinazoline

N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-fluoroquinazolin-4-amine

4-[5-(1-methyl-piperidin-4-yloxy)-quinazolin-4-ylamino]-phenol

2-chloro-4-[5-(1-methyl-piperidin-4-yloxy)-quinazolin-4-ylamino]-phenol

Refernces

• 1、 Sharma, Saurabh,Bhattacherjee, Dhananjay,Das, Pralay. "Oxalic/malonic acids as carbon building blocks for benzazole, quinazoline and quinazolinone synthesis". supporting information. p. 1337 - 1342. Retrieved 2018/03/06.
• 2、 Yoshimura, Tsutomu,Yuanjun, Di,Kimura, Yu,Yamada, Hisatsugu,Toshimitsu, Akio,Kondo, Teruyuki. "Simple, selective, and practical synthesis of 2-substituted 4(3H)-quinazolinones by Yb(OTf)3-catalyzed condensation of 2-aminobenzamide with carboxamides". . p. 857 - 865. Retrieved 2015/03/04.