<4-(trimethylammonio)butyryl>-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide chloride

Base Information

Chemical Name:<4-(trimethylammonio)butyryl>-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide chloride
CAS No.:125063-92-5
Molecular Formula:C₄₂H₆₈N₉O₆*Cl
Molecular Weight:830.512
Hs Code.:

Synonyms:<4-(trimethylammonio)butyryl>-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide chloride

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Chemical Property of <4-(trimethylammonio)butyryl>-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide chloride

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Technology Process of <4-(trimethylammonio)butyryl>-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide chloride

There total 4 articles about <4-(trimethylammonio)butyryl>-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 6249-56-5
γ-butyrobetaine hydrochloride

: 136630-78-9
H-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide dihydrochloride

: 125063-92-5
<4-(trimethylammonio)butyryl>-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide chloride

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 14h; Ambient temperature;
DOI:10.1021/jm00115a016

Reference yield:

: 118700-84-8
(S)-3-(2-(tert-butoxycarbonylamino)-3-phenyl-propanamido)propanoic acid

: 125063-92-5
<4-(trimethylammonio)butyryl>-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / N-NMM, 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

2: 4N aq. HCl / dioxane / 1 h / Ambient temperature

3: 38 percent / N-methylmorpholine (NMM), 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00115a016

Reference yield:

: 136735-33-6
H-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide dihydrochloride

: 125063-92-5
<4-(trimethylammonio)butyryl>-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / N-NMM, 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

2: 4N aq. HCl / dioxane / 1 h / Ambient temperature

3: 38 percent / N-methylmorpholine (NMM), 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00115a016