3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxamide

Base Information

Chemical Name:3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxamide
CAS No.:1428639-41-1
Molecular Formula:C₃₇H₃₀FN₃O₄
Molecular Weight:599.661
Hs Code.:

Synonyms:3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxamide

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Chemical Property of 3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxamide

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Technology Process of 3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxamide

There total 13 articles about 3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428640-02-1
3-(2-fluorophenyl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxylic acid

: 154-09-6,526-53-4,2899-29-8,52485-52-6
(2R)-2-amino-3-(1H-indol-3-yl)propan-1-ol

: 1428639-41-1
3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1428639-86-4
methyl 2'-fluoro-5-nitrobiphenyl-2-carboxylate

: 1428639-41-1
3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: iron; acetic acid / 2 h / 85 °C

2: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C

3: potassium carbonate / acetone / 4 h / Reflux

4: bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; potassium acetate / 40 h / 100 °C / Inert atmosphere

5: aluminum (III) chloride / dichloromethane / 2 h / 0 °C

6: triethylamine / dichloromethane / 0.75 h / 0 °C

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

8: water; sodium hydroxide / ethanol / 3 h / 60 °C

9: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl acetamide; sulfuric acid; water; potassium acetate; iron; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium nitrite; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 4: |Sonogashira Cross-Coupling / 7: |Suzuki Coupling;

Reference yield:

: 1428639-87-5
methyl 5-amino-2'-fluorobiphenyl-2-carboxylate

: 1428639-41-1
3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-9-methoxy-8-(pyridin-3-yl)-6H-benzo[c]chromene-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C

2: potassium carbonate / acetone / 4 h / Reflux

3: bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; potassium acetate / 40 h / 100 °C / Inert atmosphere

4: aluminum (III) chloride / dichloromethane / 2 h / 0 °C

5: triethylamine / dichloromethane / 0.75 h / 0 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

7: water; sodium hydroxide / ethanol / 3 h / 60 °C

8: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl acetamide; sulfuric acid; water; potassium acetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium nitrite; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 3: |Sonogashira Cross-Coupling / 6: |Suzuki Coupling;