1-(4'-bromophenyl)-3,3-difluoro-2-(phenylethynyl)cyclopropene

Base Information

• Chemical Name: 1-(4'-bromophenyl)-3,3-difluoro-2-(phenylethynyl)cyclopropene
• CAS No.: 852632-59-8
• Molecular Formula: C₁₇H₉BrF₂
• Molecular Weight: 331.159
• Mol file: 852632-59-8.mol

Synonyms:1-(4'-bromophenyl)-3,3-difluoro-2-(phenylethynyl)cyclopropene

Chemical Property of 1-(4'-bromophenyl)-3,3-difluoro-2-(phenylethynyl)cyclopropene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4'-bromophenyl)-3,3-difluoro-2-(phenylethynyl)cyclopropene

There total 2 articles about 1-(4'-bromophenyl)-3,3-difluoro-2-(phenylethynyl)cyclopropene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phenylacetylene (536-74-3) + 1-bromo-4-(3,3-difluoro-2-iodo-cycloprop-1-enyl)-benzene (491593-80-7) → 1-(4'-bromophenyl)-3,3-difluoro-2-(phenylethynyl)cyclopropene (852632-59-8)

Guidance literature:

With copper(l) iodide; silver carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.jfluchem.2004.10.003 DOI:10.1016/j.jfluchem.2004.10.012

Reference yield: 62.0%

phenylacetylene (536-74-3) + 1-(4-Bromophenyl)-2-chloro-3,3-difluorocycloprop-1-ene → 1-(4'-bromophenyl)-3,3-difluoro-2-(phenylethynyl)cyclopropene (852632-59-8)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; potassium carbonate; palladium diacetate; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2008.03.061

Reference yield: 70.0%

1-(4'-bromophenyl)-3,3-difluoro-2-(phenylethynyl)cyclopropene (852632-59-8) + trimethylsilyl-2,2-difluoro-2-(fluorosulphonyl)acetate (120801-75-4) → 2-(4-bromo-phenyl)-3,3,3',3'-tetrafluoro-2'-phenyl-bicyclopropyl-1,1'-diene

Guidance literature:

With sodium fluoride; In diethylene glycol dimethyl ether; at 120 ℃; for 2h;

DOI:10.1016/j.jfluchem.2004.10.003 DOI:10.1016/j.jfluchem.2004.10.012

upstream raw materials:

phenylacetylene

1-bromo-4-(3,3-difluoro-2-iodo-cycloprop-1-enyl)-benzene