(S)-N¹-[2-(2-Benzyloxy-ethylcarbamoyl)-2-hydroxy-1-methyl-ethyl]-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide

Base Information

• Chemical Name: (S)-N¹-[2-(2-Benzyloxy-ethylcarbamoyl)-2-hydroxy-1-methyl-ethyl]-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide
• CAS No.: 1027972-80-0
• Molecular Formula: C₃₁H₅₁N₅O₇
• Molecular Weight: 605.775

Synonyms:(S)-N¹-[2-(2-Benzyloxy-ethylcarbamoyl)-2-hydroxy-1-methyl-ethyl]-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide

Chemical Property of (S)-N¹-[2-(2-Benzyloxy-ethylcarbamoyl)-2-hydroxy-1-methyl-ethyl]-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide

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Technology Process of (S)-N¹-[2-(2-Benzyloxy-ethylcarbamoyl)-2-hydroxy-1-methyl-ethyl]-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide

There total 7 articles about (S)-N¹-[2-(2-Benzyloxy-ethylcarbamoyl)-2-hydroxy-1-methyl-ethyl]-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N⁴,N⁴-dimethyl-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-Butylacetic acid (1070-83-3) → (S)-N1-[2-(2-Benzyloxy-ethylcarbamoyl)-2-hydroxy-1-methyl-ethyl]-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N4,N4-dimethyl-succinamide (1027972-80-0)

Guidance literature:

Multi-step reaction with 3 steps

1: EDAC, HOBT, i-Pr₂NEt / dimethylformamide / 16 h / Ambient temperature

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr

3: HOBT, EDAC, i-Pr₂NEt / dimethylformamide / 16 h

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm970104t

Reference yield:

Boc-Asn(Me)2-OH (70232-19-8) → (S)-N1-[2-(2-Benzyloxy-ethylcarbamoyl)-2-hydroxy-1-methyl-ethyl]-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N4,N4-dimethyl-succinamide (1027972-80-0)

Guidance literature:

Multi-step reaction with 7 steps

1: EDAC, HOBT, i-Pr₂NEt / dimethylformamide / 16 h / Ambient temperature

2: HCl / dioxane / 0 °C

3: EDAC, HOBT, i-Pr₂NEt / dimethylformamide / 16 h / Ambient temperature

4: HCl / dioxane / 0 °C

5: EDAC, HOBT, i-Pr₂NEt / dimethylformamide / 16 h / Ambient temperature

6: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr

7: HOBT, EDAC, i-Pr₂NEt / dimethylformamide / 16 h

With hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm970104t

Reference yield:

3-{(S)-2-[(S)-2-(3,3-Dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-3-dimethylcarbamoyl-propionylamino}-2-hydroxy-butyric acid benzyl ester → (S)-N1-[2-(2-Benzyloxy-ethylcarbamoyl)-2-hydroxy-1-methyl-ethyl]-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-N4,N4-dimethyl-succinamide (1027972-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr

2: HOBT, EDAC, i-Pr₂NEt / dimethylformamide / 16 h

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm970104t

upstream raw materials:

O-benzylethanolamine

3-{(S)-2-[(S)-2-(3,3-Dimethyl-butyrylamino)-3,3-dimethyl-butyrylamino]-3-dimethylcarbamoyl-propionylamino}-2-hydroxy-butyric acid

tert-Butylacetic acid

Boc-Asn(Me)2-OH

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