benzyl (1S,3R)-3-((2S,3S)-4-(2-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

Base Information

Chemical Name:benzyl (1S,3R)-3-((2S,3S)-4-(2-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate
CAS No.:1313358-24-5
Molecular Formula:C₅₂H₆₀N₆O₇
Molecular Weight:881.084
Hs Code.:

benzyl (1S,3R)-3-((2S,3S)-4-(2-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

Synonyms:benzyl (1S,3R)-3-((2S,3S)-4-(2-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

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Chemical Property of benzyl (1S,3R)-3-((2S,3S)-4-(2-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

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Technology Process of benzyl (1S,3R)-3-((2S,3S)-4-(2-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

There total 5 articles about benzyl (1S,3R)-3-((2S,3S)-4-(2-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,3S)-3-(((benzyloxy)carbonyl)amino)-2,2-dimethylcyclobutan-1-carboxylic acid: 1017279-76-3
(1R,3S)-3-(((benzyloxy)carbonyl)amino)-2,2-dimethylcyclobutan-1-carboxylic acid

: 198904-87-9
(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol hydrochloride

: 1313358-24-5
benzyl (1S,3R)-3-((2S,3S)-4-(2-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

Guidance literature:: (1R,3S)-3-(((benzyloxy)carbonyl)amino)-2,2-dimethylcyclobutan-1-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃;

(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 80-57-9,1196-01-6
(-)-Verbenone

: 1313358-24-5
benzyl (1S,3R)-3-((2S,3S)-4-(2-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium periodate; water / ruthenium(III) trichloride hydrate / tetrachloromethane; acetonitrile / 12 h / 0 - 20 °C

2.1: chloroformic acid ethyl ester; triethylamine / acetone / 3 h / 0 °C

2.2: 1.5 h / 0 - 20 °C

3.1: toluene / 4 h / 0 °C / Reflux

4.1: sodium hydroxide; bromine / water / 5 h / -5 °C

4.2: pH 2 - 3

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

5.2: 16 h / 20 °C

With sodium periodate; water; bromine; chloroformic acid ethyl ester; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; ruthenium(III) trichloride hydrate; In tetrachloromethane; dichloromethane; water; acetone; toluene; acetonitrile; 4.1: Lieben degradation;

Reference yield:

: 288848-24-8
(1S,3R)-3-acetyl-2,2-dimethylcyclobutane carboxylic acid

: 1313358-24-5
benzyl (1S,3R)-3-((2S,3S)-4-(2-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarbonyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,2-dimethylcyclobutylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloroformic acid ethyl ester; triethylamine / acetone / 3 h / 0 °C

1.2: 1.5 h / 0 - 20 °C

2.1: toluene / 4 h / 0 °C / Reflux

3.1: sodium hydroxide; bromine / water / 5 h / -5 °C

3.2: pH 2 - 3

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

4.2: 16 h / 20 °C

With bromine; chloroformic acid ethyl ester; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In dichloromethane; water; acetone; toluene; 3.1: Lieben degradation;