1-(4-methoxyphenyl)-4-(4-nitrophenyl)-5-(trimethylsilyl)ethynyl-1H-pyrazole

Base Information

Chemical Name:1-(4-methoxyphenyl)-4-(4-nitrophenyl)-5-(trimethylsilyl)ethynyl-1H-pyrazole
CAS No.:1416159-20-0
Molecular Formula:C₂₁H₂₁N₃O₃Si
Molecular Weight:391.502
Hs Code.:

Synonyms:1-(4-methoxyphenyl)-4-(4-nitrophenyl)-5-(trimethylsilyl)ethynyl-1H-pyrazole

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Chemical Property of 1-(4-methoxyphenyl)-4-(4-nitrophenyl)-5-(trimethylsilyl)ethynyl-1H-pyrazole

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Technology Process of 1-(4-methoxyphenyl)-4-(4-nitrophenyl)-5-(trimethylsilyl)ethynyl-1H-pyrazole

There total 4 articles about 1-(4-methoxyphenyl)-4-(4-nitrophenyl)-5-(trimethylsilyl)ethynyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1416159-19-7
(1E)-1-ethoxy-2-(4-nitrophenyl)-5-(trimethylsilyl)pent-1-en-4-yn-3-one

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 1416159-20-0
1-(4-methoxyphenyl)-4-(4-nitrophenyl)-5-(trimethylsilyl)ethynyl-1H-pyrazole

Guidance literature:: With triethylamine; In ethanol; at 20 ℃; chemoselective reaction;
DOI:10.1002/ejoc.201200807

Reference yield:

: 50434-36-1
4-nitrophenylacetyl chloride

: 1416159-20-0
1-(4-methoxyphenyl)-4-(4-nitrophenyl)-5-(trimethylsilyl)ethynyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride / dichloromethane / 0.5 h / 0 °C

2: acetic anhydride / Reflux

3: triethylamine / ethanol / 20 °C

With aluminum (III) chloride; acetic anhydride; triethylamine; In ethanol; dichloromethane;
DOI:10.1002/ejoc.201200807

Reference yield:

: 1357356-72-9
1-(4-nitrophenyl)-4-(trimethylsilyl)but-3-yn-2-one

: 1416159-20-0
1-(4-methoxyphenyl)-4-(4-nitrophenyl)-5-(trimethylsilyl)ethynyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / Reflux

2: triethylamine / ethanol / 20 °C

With acetic anhydride; triethylamine; In ethanol;
DOI:10.1002/ejoc.201200807