(3S,6S)-3-(4-Benzyloxy-benzyl)-6-(4-hydroxy-benzyl)-1-methyl-piperazin-2-one

Base Information

Chemical Name:(3S,6S)-3-(4-Benzyloxy-benzyl)-6-(4-hydroxy-benzyl)-1-methyl-piperazin-2-one
CAS No.:849041-86-7
Molecular Formula:C₂₆H₂₈N₂O₃
Molecular Weight:416.52
Hs Code.:

Synonyms:(3S,6S)-3-(4-Benzyloxy-benzyl)-6-(4-hydroxy-benzyl)-1-methyl-piperazin-2-one

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Chemical Property of (3S,6S)-3-(4-Benzyloxy-benzyl)-6-(4-hydroxy-benzyl)-1-methyl-piperazin-2-one

Chemical Property:

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Technology Process of (3S,6S)-3-(4-Benzyloxy-benzyl)-6-(4-hydroxy-benzyl)-1-methyl-piperazin-2-one

There total 6 articles about (3S,6S)-3-(4-Benzyloxy-benzyl)-6-(4-hydroxy-benzyl)-1-methyl-piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 215596-38-6
(S)-3-(4-hydroxyphenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester

: 849041-86-7
(3S,6S)-3-(4-Benzyloxy-benzyl)-6-(4-hydroxy-benzyl)-1-methyl-piperazin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / K₂CO₃ / dimethylformamide / 20 °C

2: 82 percent / LAH / tetrahydrofuran / Heating

3: 99 percent / aq. K₂CO₃ / tetrahydrofuran / 0 °C

4: 99 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

5: 90 percent / NaBH₃CN / dimethylformamide / 0 °C

6: 99 percent / ZnBr₂ / CH₂Cl₂ / 0 °C

7: 85 percent / MeONa / tetrahydrofuran / 0 °C

8: 92 percent / CF₃CO₂H / CH₂Cl₂ / 0 °C

With lithium aluminium tetrahydride; oxalyl dichloride; sodium methylate; sodium cyanoborohydride; potassium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; zinc dibromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4: Swern oxidation;
DOI:10.1055/s-2004-836065

Reference yield:

: 849041-80-1
(S)-3-[4-(4-Methoxy-benzyloxy)-phenyl]-2-methylamino-propan-1-ol

: 849041-86-7
(3S,6S)-3-(4-Benzyloxy-benzyl)-6-(4-hydroxy-benzyl)-1-methyl-piperazin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / aq. K₂CO₃ / tetrahydrofuran / 0 °C

2: 99 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

3: 90 percent / NaBH₃CN / dimethylformamide / 0 °C

4: 99 percent / ZnBr₂ / CH₂Cl₂ / 0 °C

5: 85 percent / MeONa / tetrahydrofuran / 0 °C

6: 92 percent / CF₃CO₂H / CH₂Cl₂ / 0 °C

With oxalyl dichloride; sodium methylate; sodium cyanoborohydride; potassium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; zinc dibromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Swern oxidation;
DOI:10.1055/s-2004-836065

Reference yield:

: 849041-79-8
(S)-2-Ethoxycarbonylamino-3-[4-(4-methoxy-benzyloxy)-phenyl]-propionic acid methyl ester

: 849041-86-7
(3S,6S)-3-(4-Benzyloxy-benzyl)-6-(4-hydroxy-benzyl)-1-methyl-piperazin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / LAH / tetrahydrofuran / Heating

2: 99 percent / aq. K₂CO₃ / tetrahydrofuran / 0 °C

3: 99 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

4: 90 percent / NaBH₃CN / dimethylformamide / 0 °C

5: 99 percent / ZnBr₂ / CH₂Cl₂ / 0 °C

6: 85 percent / MeONa / tetrahydrofuran / 0 °C

7: 92 percent / CF₃CO₂H / CH₂Cl₂ / 0 °C

With lithium aluminium tetrahydride; oxalyl dichloride; sodium methylate; sodium cyanoborohydride; potassium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; zinc dibromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Swern oxidation;
DOI:10.1055/s-2004-836065